Jan 11, 1992

Experimental studies on the origin of the genetic code and the process of protein synthesis: a review update

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
J C LaceyG W Cook

Abstract

This article is an update of our earlier review (Lacey and Mullins, 1983) in this journal on the origin of the genetic code and the process of protein synthesis. It is our intent to discuss only experimental evidence published since then although there is the necessity to mention the old enough to place the new in context. We do not include theoretical nor hypothetical treatments of the code or protein synthesis. Relevant data regarding the evolution of tRNAs and the recognition of tRNAs by aminoacyl-tRNA-synthetases are discussed. Our present belief is that the code arose based on a core of early assignments which were made on a physico-chemical and anticodonic basis and this was expanded with new assignments later. These late assignments do not necessarily show an amino acid-anticodon relatedness. In spite of the fact that most data suggest a code origin based on amino acid-anticodon relationships, some new data suggesting preferential binding of Arg to its codons are discussed. While information regarding coding is not increasing very rapidly, information regarding the basic chemistry of the process of protein synthesis has increased significantly, principally relating to aminoacylation of mono- and polyribonucleotides. Incl...Continue Reading

  • References101
  • Citations28

Citations

Mentioned in this Paper

Amino Acids, I.V. solution additive
MT-TA gene
Triplet Codon-amino Acid Adaptor Activity
Transfer RNA
Protein Biosynthesis
Plasma Protein Binding Capacity
Codon (Nucleotide Sequence)
Nucleotides
Amino Acyl-tRNA Synthetases
5'-NUCLEOTIDASE

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