PMID: 39448Oct 1, 1979

Experimental studies on the pathogenesis of asystole after verapamil in the dog

The American Journal of Cardiology
F Urthaler, T N James


The effect of verapamil on automaticity and conduction in the atrioventricular (A-V) junctional region was studied in anesthetized dogs. In five normal dogs verapamil, 10 microgram/ml, was selectively perfused into the A-V nodal artery and caused first degree heart block, which progressed to second degree heart block in three of the five. Higher concentrations of verapamil, 25 microgram/ml, caused complete heart block in three of five other dogs, but no episodes of asystole (defined as a ventricular pause of 10 or more seconds). In six other dogs after beta receptor blockade with propranolol, 20 microgram/ml, perfused into the A-V nodal artery, verapamil, 10 microgram/ml, regularly caused second degree heart block; in four of the six dogs there was a transient episode of third degree A-V block, and in two of these there was a period of asystole. In each of the 10 dogs pretreated with reserpine, verapamil, 10 microgram/ml, caused third degree A-V block; in seven of these there was a period of asystole with ventricular standstill up to 30 seconds. Concentrations of verapamil that do not produce high grade heart block in the normal heart thus readily cause both high grade block and prolonged ventricular standstill after eliminatio...Continue Reading


Nov 1, 1983·Journal of the American College of Cardiology·T N James
Dec 17, 1992·The New England Journal of Medicine·J BussD L Heene
Jul 1, 1981·The Journal of Clinical Investigation·L BelardinelliR M Berne
May 1, 1983·The Journal of Clinical Investigation·H O GloorT N James
Mar 1, 1984·The American Journal of Cardiology·R YeeG J Klein
Feb 1, 1983·The American Journal of Cardiology·G CuiF Urthaler
Jan 25, 1985·The American Journal of Cardiology·M B LeonS E Epstein
Jul 1, 1981·Pacing and Clinical Electrophysiology : PACE·H G Mond
Jul 1, 1983·Biopharmaceutics & Drug Disposition·R G McAllisterM T Piascik


Aug 1, 1975·Japanese Circulation Journal·T Okada, T Konishi
May 13, 1972·British Medical Journal·D M Krikler, R Spurrell
Jan 1, 1972·Pflügers Archiv : European journal of physiology·M KohlhardtA Fleckenstein
Aug 1, 1973·American Heart Journal·F UrthalerT N James
Mar 11, 1972·British Medical Journal·L SchamrothC Garrett
Apr 15, 1972·British Medical Journal·M E Benaim

Related Concepts

Pathogenic Aspects
Heart Block
Crista Terminalis Branch of Sinoatrial Nodal Artery
Hepatitis A
Norepinephrine, (+, -)-Isomer
Congenital Heart Block
First Degree Atrioventricular Block
Sinus Node Artery

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