PMID: 2494900Mar 1, 1989Paper

Experimental studies on the replication and transmission of Crimean-Congo hemorrhagic fever virus in some African tick species

The American Journal of Tropical Medicine and Hygiene
A J ShepherdO Mathee

Abstract

Seven African tick species were studied as potential vectors of Crimean-Congo hemorrhagic fever (CCHF) virus. Engorged nymphae of 4 ixodid species, Hyalomma marginatum rufipes, H. truncatum, Rhipicephalus evertsi mimeticus, and Amblyomma hebraeum, were inoculated intracoelomically with CCHF virus and assayed for virus content at varying times post-inoculation. The virus replicated in all 4 species, reaching maximum titers of 4.6-5.5(10) fluorescence focus units per ml on days 5-9 post-inoculation. Virus titers declined up to the molt, but increased slightly on emergence of adult ticks. Thereafter, virus titers declined progressively, but infectivity could still be detected in adult ticks for up to 205 days post-inoculation. Groups of H. m. rufipes, H. truncatum, and R.e. mimeticus infected adults were fed on susceptible sheep and successfully transmitted CCHF infection. CCHF virus was not isolated from pools of the larval and nymphal progeny of the female ticks nor did the larvae transmit infection to guinea pigs by bite. CCHF virus failed to replicate in adults and nymphae of 3 argasid tick species, Argas walkerae, Ornithodorus porcinus porcinus, and O. savignyi, after intracoelomic inoculation and could be reisolated from the...Continue Reading

Citations

Oct 1, 2011·Vector Borne and Zoonotic Diseases·Lesley Bell-SakyiJohn K Fazakerley
Jul 3, 2019·Viruses·Aura R GarrisonJoseph W Golden
Apr 1, 1991·Epidemiology and Infection·A J ShepherdO Mathee
Feb 24, 2020·Veterinary Medicine and Science·Constantina N TsokanaCharalambos Billinis
Jun 9, 2005·Parasitology·M Labuda, P A Nuttall
Nov 27, 2014·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Fernando BoinasAnthony James Wilson
May 25, 2013·Transboundary and Emerging Diseases·J C LubingaE H Venter
Jan 1, 2013·Pathogens·Marko ZivcecHeinz Feldmann
Jan 8, 2016·PLoS Neglected Tropical Diseases·Jessica R SpenglerPierre E Rollin
Jul 11, 2020·Tropical Medicine and Infectious Disease·Teresa E SorvilloDennis A Bente
May 25, 2016·Scientific Reports·Marcel A MüllerChristian Drosten
Nov 18, 2014·Viruses·Kate McElroy Horne, Dana L Vanlandingham
Feb 17, 2021·Médecine sciences : M/S·Olivier ReynardViktor Volchkov
Sep 7, 2020·Travel Medicine and Infectious Disease·Enrica SerretielloMassimiliano Galdiero
Apr 27, 2005·Virology Journal·Sebastian HaferkampRamon Flick

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