Sep 1, 1976

Experimental studies on the transmission of hepatitis B by mosquitoes

The American Journal of Tropical Medicine and Hygiene
K R BerquistC A Schable

Abstract

Culex tarsalis and Aedes aegypti mosquitoes were fed on chimpanzees carrying hepatitis B surface antigen (HBS Ag) of known infectivity and pools were tested by radioimmunoassay daily for the presence of HBS Ag. HBS Ag continued to be detected at low levels in mosquito tissue after digestion of the blood meal. Inoculation of susceptible chimpanzees with macerated pools of A. aegypti mosquitoes at two intervals after digestion of the blood meal did not produce hepatitis or serologic evidence of hepatitis B virus infection. Mechanical transmission studies by interrupting feeding of A aegypti from HBS Ag-carrier chimpanzees and transferring them to susceptible chimpanzees did not produce hepatitis. These findings do not support the hypothesis that mosquitoes are involved in either biological or mechanical transmission of hepatitis B.

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Mentioned in this Paper

Tumor Virus Infections
Hepatitis B Antigens
Insect Vectors
Pan troglodytes
Hepatitis B Surface Antigens
Aedes aegypti
Hepatitis B Surface Antigen Measurement
Digestion
Hepatitis B Vaccine
Radioimmunoassay

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