PMID: 30001011May 1, 2016Paper

Experimental Study and DFT Calculation of FTIR, FT-Raman and THz-TDS Spectra of Ⅰ and Ⅲ Polymorphs of Chlorpropamide

Guang pu xue yu guang pu fen xi = Guang pu
Hong Xia FangYong Du

Abstract

The absorption spectra of Ⅰ and Ⅲ polymorphs of chlorpropamide were measured with terahertz time-domain spectroscopy (THz-TDS) technique, FT-IR and FT-Raman at room temperature. The results showed that there were distinct differences of Ⅰ and Ⅲ polymorphs of chlorpropamide in those spectra. The IR spectra of two polymorphs of chlorpropamide had showed differences both in the frequencies of the vibrational bands and in the relative band intensities. The obvious differences in Raman spectra of polymorphs of chlorpropamide were that the characteristic peaks of Ⅲ- form were more than Ⅰ-form in 100~1 800 cm-1 region. Absorption peaks observing in the terahertz spectra ofⅠ-form were at 0.90, 1.09 and 1.29 THz and Ⅲ-form were at 0.92, 1.11, 1.23 and 1.63 THz. The maximum difference between Ⅰ-form and Ⅲ-form was that the strong peak appeared at 1.63 THz of Ⅲ-form. The characteristic absorption bands of two polymorphs of chlorpropamide were assigned based on the simulation results of DFT calculation. The simulation result is in accordance with the experiment. From simulation results, it is found that the vibration modes of Ⅰ-form and Ⅲ-form were similar in IR and Raman spectra, but there were more differences in terahertz spectra. The s...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.