Experimental study evaluating the effect of a barrier method on postoperative intraabdominal adhesions.

Digestive Diseases and Sciences
Axel SchneiderUdo Rolle

Abstract

The purpose of this animal study was to determine if tissue glue-coated collagen sponge is an effective barrier method to prevent localized adhesions in a modified rabbit sidewall model. Rabbits were divided into two groups and underwent laparotomy with subsequent creation of a cecal wound according to the rabbit sidewall model. Rabbits of group I (treatment group; n = 10) were treated with a TachoComb H patch placed on the defect, whereas group II animals (control group; n = 6) did not receive further treatment. All animals were sacrificed 2 weeks postoperatively and adhesions were evaluated using special adhesion score. A further six rabbits underwent TachoComb H application at the cecum to investigate the histological changes during a course of 12 weeks. The average adhesion scores were significantly (P < 0.05) reduced in the treatment group compared to the controls. Histologically the TachoComb H patch was surrounded by granulation tissue without signs of infection. Tissue glue-coated collagen sponge (TachoComb H) is effective to prevent localized intraabdominal adhesions in the modified rabbit sidewall model.

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Citations

Jul 12, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Y AltınelH Özgüç
Jul 4, 2013·Journal of Materials Science. Materials in Medicine·Zengjuan ZhengHeidi M Mansour
Jul 1, 2014·The Journal of Surgical Research·Flávio D SabinoRuy G Marques
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Eduardo Esteban Montalvo-JavéJesús Tapia Jurado
Jun 17, 2009·Expert Opinion on Biological Therapy·Andreas RickenbacherAndrea Frilling
Oct 23, 2012·The Annals of Thoracic Surgery·Tarah J KuschelHeike Schnoering
Dec 25, 2009·The Journal of Surgical Research·Katy L TownsendMatthew J Allen
Feb 3, 2015·The Journal of Thoracic and Cardiovascular Surgery·Norifumi TsubokawaMorihito Okada
Apr 24, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jacopo VannucciFrancesco Puma
Jul 10, 2007·International Journal of Surgery·Emre Ergul, Birol Korukluoglu
Dec 1, 2006·The Journal of International Medical Research·G DickneiteD Rosenthal
Jun 7, 2014·Surgical Innovation·Luis Tallón-AguilarJavier Padillo-Ruiz
Sep 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Deha Erdogan, Thomas M van Gulik
Dec 22, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tyge NordentoftMichael Sørensen

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