[Experimental study in rats on the renal compatibility of cephalothin and cephalothin-aminoglycoside combinations (author's transl)].

Infection
J Wilhelm, K Sack

Abstract

The possible nephrotoxity of cephalothin and the antibiotic combinations cephalotin-gentamicin and cephalothin-tobramycin was investigated in standardized animal experiments. Toxicity parameters were blood-urea concentration, the urinary enzymes GOT, LDH, MDH and the cell excretion rate, supplemented by histological investigations of the kidneys. Compared with other cephalosporine derivates, the antibiotic cephalothin in a toxic threshold-dose of 3000 mg/kg/day proved to be realtively well tolerated by the kidneys. On comparison with the respective monotherapy, the renal tolerance for cephalothin-aminoglycoside combinations was reduced. The clinical value of these findings is discussed.

References

Jul 1, 1970·The Journal of Infectious Diseases·F SilverblattR Bulger
May 1, 1966·Toxicology and Applied Pharmacology·R M AtkinsonE G Tomich
Mar 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·R C VenutoT F Ferris
Apr 1, 1970·Southern Medical Journal·M J PickeringJ R Cade
Oct 1, 1970·British Journal of Pharmacology·M G Dodds, R D Foord
Dec 12, 1968·The New England Journal of Medicine·J J RahalL Weinstein
Nov 11, 1966·Deutsche medizinische Wochenschrift·W Steinbrunn, U P Haemmerli
May 1, 1966·Toxicology and Applied Pharmacology·R M AtkinsonE G Tomich
Dec 1, 1963·The American Journal of the Medical Sciences·R J BULGER, W M KIRBY

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Citations

Oct 1, 1977·Antimicrobial Agents and Chemotherapy·J S WoldN V Owen

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