Experimental study of acid burden and acute oesophagitis

The British Journal of Surgery
K G PursnaniD O Castell

Abstract

The relationship of the pH of oesophageal refluxate and its pepsin content to injury of oesophageal mucosa remains unclear. A study was made of the earliest morphological alterations in the oesophageal mucosa secondary to varying concentrations of hydrochloric acid with or without pepsin. Adult cats had varying concentrations of acid with and without 1 per cent porcine pepsin infused into the oesophagus through a paediatric feeding tube placed 5 cm above the oesophagogastric junction at a rate of 1 ml/min for 30 min. At autopsy 24 h later, the oesophagus was removed intact and scored by an expanded modification of a previously published histopathological scoring system. This included estimates of the intensity and distribution of four morphological features: basal cell hyperplasia (BCH), intraepithelial leucocytes (IELs), subepithelial leucocytes and ulcers. Each of these four categories was scored from 0 to 4, with a maximum injury score of 16. Mean(s.e.m.) scores were as follows: pH 1, 15.0(1.0); pH 1 with pepsin, 13.3(1.4); pH 2, 15.3(0.7); pH 2 with pepsin, 11.7(1.1); pH 3, 1.8(1.6); pH 3 with pepsin, 3.7(1.9); pH 4 with or without pepsin, 0.6(0.2). Differences between pH 3 and 4 versus pH 1 and 2 were significant (P < 0.05...Continue Reading

References

Oct 1, 1976·Annals of Surgery·T R DemeesterD B Skinner
Jul 1, 1977·The American Journal of Digestive Diseases·R S ChungL Denbesten
Feb 1, 1992·The British Journal of Surgery·G ZaninottoE Ancona
Jan 1, 1991·Journal of Clinical Gastroenterology·R C Orlando
Jan 1, 1986·Journal of Clinical Gastroenterology·L F Johnson, J W Harmon
Feb 1, 1988·Digestive Diseases and Sciences·P O KatzD O Castell
Jan 1, 1986·Journal of Clinical Gastroenterology·L F Johnson, T R DeMeester
Jun 1, 1969·The Biochemical Journal·A J Cornish-Bowden, J R Knowles
Jan 1, 1981·Digestive Diseases and Sciences·J W HarmonC L Maydonovitch

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Citations

Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S J WalkerN Birbeck
Dec 11, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y Koak, M Winslet
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Yvone VicenteJuan A Tovar
Dec 14, 2004·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H TuğtepeTolga E Dağli
Jul 7, 2012·Clinical and Experimental Gastroenterology·Massimo P Di SimoneGilberto Poggioli
Dec 13, 2005·Drugs·Xavier Calvet, Fernando Gomollón
May 15, 2004·Alimentary Pharmacology & Therapeutics·J Hammer, B Schmidt
Feb 12, 2004·Alimentary Pharmacology & Therapeutics·R TutuianP O Katz
Jan 20, 2005·The Medical Clinics of North America·Roy C Orlando
Mar 5, 2003·Alimentary Pharmacology & Therapeutics·J G Hatlebakk
Nov 28, 2001·The American Journal of Gastroenterology·N A TobeyR C Orlando
Nov 24, 2004·The American Journal of Gastroenterology·Talal AdhamiMichael F Vaezi
Nov 24, 2004·The American Journal of Gastroenterology·Brenda C WesthoffPrateek Sharma
May 9, 2015·World Journal of Gastroenterology : WJG·Rui-Hua Wang
Jul 20, 2004·World Journal of Gastroenterology : WJG·Xiao-Wei Shuai, Peng-Yan Xie
Jan 1, 2021·Clinical and Translational Science·Deok Y YoonSeungHwan Lee
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chiara AgostinisRoberta Bulla

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