Experimental study of coil embolization using a new atelocollagen spring coil

Pediatric Research
T InoH Ito

Abstract

Spring steel coils have been used to occlude abnormal vessels in patients with a congenital heart malformation. However, long-term adverse effects of steel spring coils remain uncertain, although some long-term results appear to be good. The purpose of this study was to evaluate the angiographic and histologic results of coil embolization experimentally using a biodegradable atelocollagen coil that we have recently developed. The spring coil was made from a 30% atelocollagen solution mixed with a contrast medium. The delivery system consisted of a 5-F end-hole catheter and a 3-F modified biotome catheter as a catch and release system. Coil embolization was percutaneously attempted in 12 dogs, and only one coil was placed in each dog so that a variety of endothelial coverage could be evaluated both in complete and incomplete occlusion. At 1 wk to 5 mo after the procedure, the occluded vessels were resected and examined histologically. Postprocedural angiography showed complete occlusion in 6 of the 12 vessels and partial occlusion in 6. Follow-up angiography showed complete occlusion in 8 and incomplete occlusion in 4. Histologic examination revealed that diffuse thrombosis around the coil loops and the exchange between blood an...Continue Reading

References

Jan 1, 1989·Journal of the American College of Cardiology·S B PerryJ E Lock
May 1, 1995·Journal of the American College of Cardiology·R VermaJ E Lock
Mar 1, 1994·Journal of the American College of Cardiology·J W MooreW C Kirby
Aug 1, 1993·Journal of Periodontology·Y NumabeK Kamoi
May 1, 1996·Cardiovascular and Interventional Radiology·M B NeussD A Redel
Jul 1, 1996·Journal of the American College of Cardiology·D ShimT R Lloyd

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Citations

Mar 5, 2002·Journal of Vascular and Interventional Radiology : JVIR·Mehrdad SalamatAnthony C Venbrux

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