PMID: 15376393Sep 21, 2004Paper

Experimental study of Ginkgo biloba exocarp polysaccharides on HL-60 cells in vitro

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Ai-Hua XuBu-Chan Sun

Abstract

To study the effect of Ginkgo biloba exocarp polysaccharides (GBEP) on HL-60 cells in vitro. Cell culture, MTT, flow cytometry were performed to observe proliferation, apoptosis and changes of relevant gene expression of HL-60 cells. GBEP (40-160 mg/L, 48 h) could inhibit HL-60 cells proliferation and the expression of proliferation-promotion gene c-myc, induce HL-60 cells apoptosis and down-regulate the expression of apoptosis-inhibitory gene bcl-2. Influence of GBEP on HL-60 cells proliferation and apoptosis may relate to its effects on the expression of proliferation-promotion gene c-myc and apoptosis-inhibitory gene bcl-2.

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Ping LuHua-Sheng Chen
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Liu-qing YangJie Liu
© 2021 Meta ULC. All rights reserved