Experimental study of laminar blood flow through an artery treated by a stent implantation: characterisation of intra-stent wall shear stress

Journal of Biomechanics
Nicolas BenardRobert Perrault

Abstract

The stimulation of endothelial cells by arterial wall shear stress (WSS) plays a central role in restenosis. The fluid-structure interaction between stent wire and blood flow alters the WSS, particularly between stent struts. We have designed an in vitro model of struts of an intra-vascular prosthesis to study blood flow through a 'stented' section. The experimental artery consisted of a transparent square section test vein, which reproduced the strut design (100x magnifying power). A programmable pump was used to maintain a steady blood flow. Particle image velocimetry method was used to measure the flow between and over the stent branches, and to quantify WSS. Several prosthesis patterns that were representative of the total stent strut geometry were studied in a greater detail. We obtained WSS values of between -1.5 and 1.5Pa in a weak SS area which provided a source of endothelial stimulation propitious to restenosis. We also compared two similar patterns located in two different flow areas (one at the entry of the stent and one further downstream). We only detected a slight difference between the weakest SS levels at these two sites. As the endothelial proliferation is greatly influenced by the SS, knowledge of the SS modi...Continue Reading

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Citations

Jul 19, 2006·Australasian Physical & Engineering Sciences in Medicine·L ShenY Zeng
Jun 27, 2006·Annals of Biomedical Engineering·Nicolas BenardDamien Coisne
Feb 12, 2008·Annals of Biomedical Engineering·Minsuok KimHui Meng
Apr 22, 2009·Annals of Biomedical Engineering·John CharonkoPavlos Vlachos
May 2, 2009·Annals of Biomedical Engineering·Marie A PunchardValerie Barron
Feb 15, 2011·Artificial Organs·Zengsheng ChenZaipin Xu
Aug 27, 2005·Journal of Biomechanical Engineering·Yong HeJames E Moore
Aug 10, 2011·Journal of Biomechanical Engineering·Juan MejiaOlivier F Bertrand
Mar 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroki TateishiUNKNOWN investigators of the ABSORB Cohort B study
Oct 2, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicola ViceconteCarlo Di Mario
Dec 2, 2014·Computer Methods in Biomechanics and Biomedical Engineering·Zengsheng ChenXiaoyan Deng
May 7, 2008·Biomedical Materials·Isam FaikOlivier Bertrand
Sep 26, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Zengsheng ChenZaipin Xu
Jun 25, 2008·Physics in Medicine and Biology·Tong-Miin LiouTe-Chuan Wang
Oct 17, 2019·Cardiovascular Engineering and Technology·Xiang ShenKaikai Lu
Dec 5, 2019·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Hitomi AnzaiMakoto Ohta
May 11, 2017·Clinical Neuroradiology·M Aguilar PérezH Henkes

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