Experimental study of stability of a contrast agent in an ultrasound field

Ultrasound in Medicine & Biology
J Wu, J Tong

Abstract

Attenuation coefficient and phase velocity measurements and direct optical observations showed that microbubbles of a contrast agent (Albunex) in 5% bovine albumin solution were not stable under ultrasonic irradiation. When the concentration of Albunex was 0.41 microL/mL and a 2.5-MHz phased array transducer of a Hewlett-Packard ultrasound imaging system (Model 77020AC) was used as the ultrasound source (the compression and rarefaction peak pressure amplitudes were, respectively, equal to 2 MPa and 1 MPa, the repetition frequency was 2.64 kHz), the attenuation coefficient at 2.5 MHz dropped from 40 dB/cm to 16 dB/cm after 2 min of continuous insonification. Under a static condition, it was shown by direct optical observations that the microbubbles shrank and aggregated to form clusters or were destroyed under insonification; pressure amplitude was estimated to be 0.5 MPa, frequency = 2.44 MHz, and the pulse repetition frequency was 5 kHz.

References

Nov 1, 1976·The Journal of the Acoustical Society of America·D L Miller

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Citations

Aug 16, 2000·Ultrasound in Medicine & Biology·V SborosW N McDicken
Oct 29, 2000·Ultrasound in Medicine & Biology·M WardJ F Chiu
Jul 13, 2002·Ultrasound in Medicine & Biology·C M MoranW N McDicken
May 17, 2003·Ultrasound in Medicine & Biology·Junru WuWilliam Dewitt
May 20, 2003·Ultrasound in Medicine & Biology·V SborosW N McDicken
Dec 2, 1998·Ultrasound in Medicine & Biology·Y DoidaM W Miller
Feb 27, 1999·Ultrasound in Medicine & Biology·D L MillerJ E Morris
Feb 25, 2000·Ultrasound in Medicine & Biology·W T Shi, F Forsberg
May 20, 2008·Advanced Drug Delivery Reviews·Vassilis Sboros
Dec 22, 2007·Ultrasound in Medicine & Biology·Atsuko AoiTetsuya Kodama
May 21, 1999·The Journal of the Acoustical Society of America·M WardJ F Chiu
Feb 20, 2004·Physics in Medicine and Biology·V SborosW N McDicken
Nov 26, 2002·Investigative Radiology·Jean-Michel CorreasGeneviève Berger
May 2, 2000·The Journal of the Acoustical Society of America·X A VerbeekA P Hoeks
Aug 25, 2006·Progress in Biophysics and Molecular Biology·Junru Wu

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