Experimental study of sucralfate intervention for paraquat poisoning in rats

Environmental Toxicology and Pharmacology
Zhu JunboYang Chun'ai

Abstract

This study explored the effects of sucralfate intervention as a novel treatment for paraquat (PQ) poisoning in Sprague-Dawley (SD) rats. After PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Then, the rats were administered normal saline, sodium bicarbonate solution, or sucralfate suspension as an intervention by gastric lavage. At 1, 3, 6, and 10days after poisoning, the left lungs of some rats were removed to determine the lung wet/dry (W/D) weight ratio. Additionally, the serum cytokine levels were measured, and the lung and kidney tissues were pathologically examined. After treatment, the signs and symptoms of the rats were improved, the mortality rate was reduced, the W/D weight ratio of the lung was lower, the cytokine levels [transforming growth factor (TGF)-β1, interleukin (IL)-10, and tumor necrosis factor (TNF)-α] were decreased, and the pathological injuries of the lungs and kidneys were improved. Moreover, sucralfate was significantly more effective than the control (normal saline) group and the SB treatment group. The results showed that early gastrointestinal lavage with su...Continue Reading

Citations

Oct 6, 2017·Toxicology and Industrial Health·Jianshe MaXianqin Wang
Jun 20, 2019·International Journal of Environmental Research and Public Health·Yiming ShaoZhijun Zhou
Feb 20, 2020·Military Medicine·Rajeev JaundooTravis J A Craddock
Feb 3, 2021·Critical Reviews in Toxicology·Rajasekaran Subbiah, Rajnarayan R Tiwari
Jul 21, 2021·Scientific Reports·Mikhail SyromyatnikovVasily Popov

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