Experimental study of the biocompatibility of a new glass-ionomer root canal sealer (Ketac-Endo)

Journal of Endodontics
I KolokurisI Vlemmas

Abstract

Ketac-Endo, a new glass-ionomer cement for endodontic use as root canal sealer, and Tubli-Seal were tested for tissue biocompatibility in rat connective tissue. Forty-four white female Wistar-Furth rats were used. Each sealer was placed in Teflon tubes and implanted subcutaneously. The implants were removed after 5, 15, 60, and 120 days; fixed; and histologically prepared for microscopical evaluation. Mild inflammatory reaction was observed with Ketac-Endo on the 5th day. The connective tissue was infiltrated with plasma cells. Lymphocytes and macrophages were observed. The intensity of the reaction diminished by the 15th day, and this reduction continued progressively through the 60th and 120th days. Severe inflammation with differing extensions of necrosis was observed with Tubli-Seal on the 5th and 15th days, and the material remained irritating even after long-term implantation periods (60 and 120 days).

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Citations

May 20, 1998·Journal of Endodontics·P BeltesA H Kortsaris
Feb 12, 2004·International Endodontic Journal·M A A De Bruyne, R J G De Moor
Jul 31, 2003·International Endodontic Journal·A E KaplanA M Ubios
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Oct 31, 2012·International Dental Journal·Zahed Mohammadi, Sousan Shalavi
Feb 11, 2011·International Endodontic Journal·M Karapınar-KazandağG Bayırlı
Jan 23, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David C ThomShimon Friedman
Aug 3, 2001·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·W Geurtsen
Jun 1, 2007·Journal of Applied Oral Science : Revista FOB·João E Gomes-FilhoFrancisco J Souza-Filho
Dec 10, 2002·Journal of Endodontics·T SchwarzeW Geurtsen
Aug 21, 2003·Journal of Cellular and Molecular Medicine·R L De Oliveira MusselC A Mandarim-De-Lacerda
Feb 24, 2001·Journal of Endodontics·V PatelS Friedman
Feb 24, 2001·Journal of Endodontics·C A CostaJ Hebling
May 22, 1998·Journal of Dentistry·R StrangD Woods

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