Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats.

Parasitology Research
Juliette GuitardNathalie Kapel

Abstract

To date, there is no efficient treatment for cryptosporidiosis and parasite eradication relies on innate and acquired immunity. In this study, we investigated the effect of administration of probiotic bacteria on the development and progression of the experimental infection in suckling rats. Rats were fed daily with 2.10(7) CFU of Lactobacillus casei-containing mixture, starting 2 days before the infection until the spontaneous clearance of the parasite. Effects on weight gain, parasite burden, mucosal histology and production of mucosal cytokines (IFNgamma, IL10 and TNFalpha) were studied. Although a trend to a more rapid clearance of parasites was noted in rats treated with probiotics, no significant effect of probiotics administration was observed in terms of weight gain, parasite burden, mucosal damage, or kinetics of mucosal cytokines during the course of infection. Overall, our results showed that the daily administration of L. casei-containing mixtures was unable to eradicate the parasite in our model.

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Citations

Aug 28, 2012·International Journal of General Medicine·Roger WumbaMarc Thellier
Sep 23, 2011·Pakistan Journal of Biological Sciences : PJBS·Zatollah AsemiMohamad Esmaiel Shahaboddin
Aug 5, 2014·Trends in Parasitology·Gustavo Marçal Schmidt Garcia MoreiraFabricio Rochedo Conceição
Oct 4, 2011·Journal of Parasitology Research·Marie-Agnès TraversPhilippe Grellier
Jul 28, 2009·Experimental Parasitology·Jean-François Rossignol
Dec 11, 2007·International Immunopharmacology·Ma Auxiliadora Dea-AyuelaFrancisco Bolás-Fernandez
May 15, 2012·Experimental Parasitology·Ebtisam M Al-Mathal, Afaf M Alsalem
Jan 28, 2015·Preventive Veterinary Medicine·A DelafosseC Paraud
May 20, 2016·Parasitology Research·Valeria F Del CocoMaría Alejandra Córdoba
Sep 17, 2013·Revista Do Instituto De Medicina Tropical De São Paulo·Luciana Farias da Costa de AvilaCarlos James Scaini
Sep 14, 2010·Memórias do Instituto Oswaldo Cruz·Paula G ChiodoJuan A Basualdo
Jun 2, 2016·Infection and Immunity·Cynthia L ChappellJames Hixson
Feb 9, 2007·Neonatal Network : NN·Susan Givens Bell

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