Experimental study on operative methods of pancreaticojejunostomy with reference to anastomotic patency and postoperative pancreatic exocrine function.

World Journal of Gastroenterology : WJG
Ming-Dong BaiShu-You Peng

Abstract

To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. After 4 wk ligation, a total of 36 piglets were divided randomly into four groups. The piglets in the control group underwent laparotomy only; the others were treated by three anastomoses: (1) end-to-end pancreaticojejunostomy invagination (EEPJ); (2) end-to-side duct-to-mucosa sutured anastomosis (ESPJ); or (3) binding pancreaticojejunostomy (BPJ). Anastomotic patency was assessed after 8 wk by body weight gain, intrapancreatic ductal pressure, pancreatic exocrine function secretin test, pancreatography, and macroscopic and histologic features of the anastomotic site. The EEPJ group had significantly slower weight gain than the ESPJ and BPJ groups on postoperative weeks 6 and 8 (P < 0.05). The animals in both the ESPJ and BPJ groups had a similar body weight gain. Intrapancreatic ductal pressure was similar in ESPJ and BPJ. However, pressure in EEPJ was significantly higher than that in ESPJ and BPJ (P < 0.05). All three functional parameters, the secretory volume, the flow rate of pancreatic juice, and bicarbonate concentration, ...Continue Reading

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Citations

May 6, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroyuki NakamuraTaijiro Sueda
Jun 23, 2009·Journal of Surgical Oncology·Parul J ShuklaVijay Naraynsingh
Jun 30, 2011·Journal of Surgical Oncology·Chunping JiangYitao Ding
Apr 9, 2015·Gastroenterology Research and Practice·Katarzyna KusnierzPawel Lampe
Nov 1, 2016·Surgical Innovation·Yashodhan S KhajancheeChet W Hammill
Feb 1, 2020·Scientific Reports·Nader BakheetSong Cheol Kim
Jun 13, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Hoon ParkSong Cheol Kim

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