PMID: 22332513Feb 16, 2012Paper

Experimental study on protective effect of early motion on articular cartilage after joint allograft

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Xiang LiJiuzheng Deng

Abstract

To investigate the protective effect of early motion on articular cartilage after joint allograft by performing a controlled trial between different post-operation strategies after joint allograft in an animal model. Twenty hemi-knee joints were harvested from 10 6-month-old New Zealand white rabbits (male or female, weighing 2.5-3.0 kg); 10 hemi-knee joints by deep frozen treatment (donors) were transplanted to unilateral knee joints (recipients) of 10 6-month-old Chinchilla rabbits (male or female, weighing 2.5-3.0 kg), which were divided into early motion group (n = 5) and sustained fixation group (n = 5); and 10 hemi-knee joints were used as blank control (n = 5) and frozen control (n = 5). The articular cartilage of allogenic joints was detected by X-ray film, gross, and histology at 6 weeks after operation. Gross observation: no obvious limitation of joint movements was observed in early motion group, but obvious limitation in sustained fixation group. X-ray films: the bone ends between donor and recipient healed well with good para position and alignment on the operation day and 2 weeks after operation; at 6 weeks, angulation deformity was observed in early motion group of 3 rabbits, and para position and alignment were ...Continue Reading

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