PMID: 375341Apr 23, 1979Paper

Experimental study on tissue and cell reactions after implantation of xenogeneic collagen sponges (author's transl)

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
K Remberger, G Hübner

Abstract

164 inbred Wistar rats received subcutaneous and intraperitoneal implants of xenogeneic collagen sponges and were examined by light- and electron microscopy as well as immunohistologically, to establish tissue and cell reactions and the time of collagen reabsorption. 4 to 5 weeks after implantation the xenogeneic collagen sponge was completely absorbed. All the inflammatory and reparative reactions were non-specific. Granulation tissue appeared soon (3 days after implantation) with new synthesis of fine collagen fibrils, mainly of type III, followed by type I collagen fibers. Myofibroblasts, with intracellular evidence of myosin and collagen (Type I and III) were sporadically present in the granulation tissue after day 5 and regularly after day 10. Small scar granulomas without xenogenic collagen were detectable even 4 to 6 months after collagen implantation. Reabsorption and regression of collagen granulomas occurred faster after xenogeneic collagen implantation than after using surgical cat sutures. From the morphological point of view, there is no indication of specific sensitization against xenogeneic collagen or of a specific immunologic process.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A L HorwitzR G Crystal
Sep 12, 1974·The New England Journal of Medicine·E D Harris, S M Krane
Mar 1, 1974·The Journal of Clinical Investigation·R Jaffe, D Deykin
Jan 1, 1977·Upsala Journal of Medical Sciences·D BergqvistA Ståhl

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Citations

Jan 1, 1993·International Journal of Legal Medicine·P BetzW Eisenmenger
Oct 18, 2018·Journal of Wound Care·Frank PallaskeJoachim Boese-Landgraf
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K Spanel-Borowski
May 1, 1982·Journal of Biomedical Materials Research·M Chvapil

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