Experimental therapy

Hematology/oncology Clinics of North America
S Charache

Abstract

Bone marrow transplantation, hydroxyurea therapy in children and in patients with sickling disorders other than sickle cell anemia, and prophylactic transfusion for prevention of stroke in children are currently being evaluated as treatments for patients with sickle cell disease. Long-term complications of each of these treatments are incompletely understood. Attempts to inhibit sickling by lowering intracellular hemoglobin concentration are still in progress. Combinations of therapeutic agents with different modes of action, and development of more effective treatment schedules, may further improve the outlook of patients with sickling disorders.

References

Sep 28, 1995·The New England Journal of Medicine·J M Leiden
Jan 14, 1993·The New England Journal of Medicine·G P RodgersA W Nienhuis
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·S L McCuneT M Townes

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Citations

Feb 11, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·D R Lawrenz

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