Experimental transmission of Leishmania tropica to hamsters and mice by the bite of Phlebotomus sergenti

Microbes and Infection
Milena Svobodova, Jan Votypka

Abstract

Phlebotomus sergenti is a natural vector of Leishmania tropica. However, the ability of P. sergenti to transmit L. tropica by bite has not been proven experimentally yet. We have transmitted L. tropica to golden hamsters and BALB/c mice by the bite of P. sergenti. Sand flies and Leishmania both originated from an anthroponotic cutaneous leishmaniasis focus in Urfa, Turkey. P. sergenti females from a laboratory colony were infected by feeding on lesions of needle-inoculated hamsters or mice. Gravid females were allowed to refeed on uninfected hosts 9-15 d after the infective feeding. At the second feeding, some infected females took a full blood meal, while others only a partial one; some females failed to feed at all. The ability of infected females to take a blood meal did not correlate with the parasite transmissibility. In four BALB/c mice, lesions developed after 1-6 months. In two albino hamsters (Mesocricetus auratus), lesions developed 1 month after the infective feeding, and Leishmania could be reisolated from these sites. Another hamster did not develop a lesion; however, the feeding site and the adjacent ear were PCR positive 1 year after infective feeding. Our results show that dissemination to other parts of host bo...Continue Reading

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Citations

Dec 4, 2009·Parasites & Vectors·Wossenseged LemmaAsrat Hailu
Jul 21, 2010·PLoS Neglected Tropical Diseases·Inmaculada MorenoAlfredo Toraño
Feb 24, 2006·Diagnostic Microbiology and Infectious Disease·Milan JirkùJulius Lukes
Mar 24, 2015·Parasitology Research·H M Navea-PérezJ Martín-Sánchez
Nov 9, 2018·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Najla CharguiHamouda Babba
Aug 24, 2021·Frontiers in Veterinary Science·M Magdalena AlcoverRoser Fisa

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