Experimental Traumatic Brain Injury Results in Long-Term Recovery of Functional Responsiveness in Sensory Cortex but Persisting Structural Changes and Sensorimotor, Cognitive, and Emotional Deficits

Journal of Neurotrauma
Victoria P A JohnstoneSandy R Shultz

Abstract

Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies, we have shown that experimental TBI caused an immediate (24-h post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex and how these changes may contribute to a range of TBI morbidities. Adult male Sprague-Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks of recovery before behavioral assessment, magnetic resonance imaging, and electrophysiological recordings from the barrel cortex. TBI rats demonstrated sensorimotor deficits, cognitive impairments, and anxiety-like behavior, and this was associated with significant atrophy of the barrel cortex and other brain structures. Extracellular recordings from ipsilateral barrel cortex revealed normal neuronal responsiveness and diffusion tensor MRI showed increased fractional anisotropy, axial diffusivity, and tract density within this region. These findings suggest that long-term recovery of neuronal responsiveness is owing to structural reorganization within this region. Therefore, it is likely that long-term structural and fu...Continue Reading

References

Mar 1, 1992·Journal of Neuropathology and Experimental Neurology·A Yaghmai, J Povlishock
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Mar 11, 2000·Journal of Neurophysiology·D J PintoD J Simons
Dec 6, 2001·Current Treatment Options in Neurology·David B. ArciniegasPeter Wagner
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ehsan ArabzadehMathew E Diamond
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Apr 21, 2007·The European Journal of Neuroscience·R RajanJustin L Bourke
Dec 9, 2008·Journal of Neurotrauma·Nigel C JonesTerence J O'Brien
Jan 23, 2010·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Jane GalvinChristine Imms
May 15, 2010·Applied Neuropsychology·Andrew S Davis, Raymond S Dean
May 28, 2010·Journal of Neurotrauma·Brent E Masel, Douglas S DeWitt
Nov 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ying R LiuViviane Bouilleret
Dec 24, 2010·British Journal of Pharmacology·Niklas Marklund, Lars Hillered
May 18, 2012·Journal of Neurologic Physical Therapy : JNPT·Chantel T DebertSean Dukelow
Jan 4, 2013·PloS One·Dasuni S AlwisRamesh Rajan
Jan 11, 2013·Journal of Neurotrauma·Michael J HylinPramod K Dash
Apr 2, 2013·Journal of Neurosurgery·Shawna FarquharsonAlan Connelly
Jun 8, 2013·Stroke; a Journal of Cerebral Circulation·Thomas C HarrisonTimothy H Murphy

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Citations

Jun 18, 2016·Frontiers in Systems Neuroscience·Simone F CarronRamesh Rajan
Jan 11, 2018·Brain Sciences·Saurav BhowmickP M Abdul-Muneer
May 19, 2018·Journal of Neuroscience Research·Wei OuyangWeibin Yang
Dec 12, 2017·Brain Injury : [BI]·Maddison R JohnstoneStuart J McDonald
Jul 26, 2019·The Journal of Comparative Neurology·Simone F CarronRamesh Rajan
Jul 27, 2018·Scientific Reports·Hui ChenCatherine A Gorrie
Mar 26, 2019·Journal of Neurotrauma·Sandy R ShultzRichelle Mychasiuk
Dec 23, 2019·NeuroImage. Clinical·Abdalla Z MohamedFatima A Nasrallah
Feb 18, 2021·Biological Research·Matías LiraWaldo Cerpa
Oct 15, 2020·Journal of Neurotrauma·Juliana PopovitzHita Adwanikar
Jul 3, 2021·International Journal of Molecular Sciences·Xavier Ekolle Ndode-EkaneAsla Pitkänen
Aug 27, 2021·Neuroscience and Biobehavioral Reviews·Matthieu FaillotSuhan Senova

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