May 1, 1977

Experimental trypanosomiasis in rabbits infected by Trypanosoma equiperdum: some aspects of immune response and coagulation disorders (author's transl)

Annales De Parasitologie Humaine Et Comparée
A CapbernR Pautrizel


Some aspects of immune response and coagulation disorders are investigated on rabbits infected by two strains of Trypanosoma (Trypanozoon) equiperdum giving diseases with different clinical expression. The study of antibodies to trypanosomes emphasizes the high immunogenicity of specific antigenic type glycoprotein, antigenicity of which seems to inhibit common antigens expression. Significant increase of anti-fibrinogen antibodies is discussed in relation with the presence of autoantibodies frequently discovered along trypanosomiasis. As IgM they contribute to the classical hypermacroglobulinemia of these diseases. Their casual contribution in the contribution in the casual contribution in the observed disorders is argued. The meaning of fibrinolytic system activation which is shown by FDP significant increase is equally argued: secondary fibrinolysis or Hageman Factor activation mediated by immune complexes.

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Mentioned in this Paper

Immune Response
Precipitin Tests
Trypanosoma equiperdum
Fibrinogen Assay
Antigenic Specificity

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