Experimental use of an elastomeric surgical sealant for arterial hemostasis and its long-term tissue response

Interactive Cardiovascular and Thoracic Surgery
Shinichiro OdaRyuji Tominaga

Abstract

Reliable suture line hemostasis should improve the outcome of aortic surgery. We examined the hemostatic effect and the tissue response of a novel elastomeric surgical sealant. Using porcine internal carotid arteries, we performed 16 end-to-end anastomoses with four stitches of simple interrupted sutures under full heparinization. The anastomoses were divided into two groups (eight anastomoses per group). Either novel sealant or fibrin glue was applied. The amount of bleeding was measured during the 30 s period after removing the vascular clamp. In a separate experiment, we applied the novel sealant around the abdominal aorta of rabbits (n=6) to assess the effect of the elastomeric property of the sealant on arterial wall histology. For comparison, we applied cyanoacrylate, which has no elastomeric property (n=6). A histological study was performed three months after the operation. The novel sealant prevented arterial bleeding. The amount of bleeding from the anastomoses applied with novel sealant and fibrin glue was 0.12+/-0.03 g vs. 91.8+/-16.5 g, respectively (P<0.001). Thinning of the rabbit aortic wall was observed in the cyanoacrylate-treated abdominal aorta, whereas no thinning was observed in the novel sealant group. Hi...Continue Reading

References

Jul 1, 1990·The Annals of Thoracic Surgery·T L MatthewS P Nolan
Aug 14, 2002·The Annals of Thoracic Surgery·Jurgen PassageMark F O'Brien
Aug 28, 2007·The Annals of Thoracic Surgery·Kenton J Zehr
Sep 4, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Masataka EtoTakehisa Matsuda

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Citations

Sep 20, 2011·Archives of Oral Biology·Liang ZhangYin Ding
Mar 24, 2016·Annual Review of Materials Research·Richard T TranGuillermo A Ameer
May 31, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eiji KondohMasaki Mandai
Jul 14, 2019·General Thoracic and Cardiovascular Surgery·Shigeki MoritaRyuji Tominaga

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