PMID: 7034238Dec 1, 1981Paper

Experimental vaccination with Candida albicans ribosomes in cyclophosphamide-treated animals

Sabouraudia
E Segal, Hana Sandovsky-Losica

Abstract

A study was carried out to determine whether protection against experimental systemic candidiasis can be induced by vaccination with Candida albicans ribosomes in animals compromised by cyclophosphamide (CY) treatment. ICR mice treated with CY showed a reduction in the number of leukocytes and a decrease in spleen and body weights. CY-treated mice were more susceptible to intraperitoneal (IP) or intravenous (IV) challenge with live C. albicans than the untreated animals. Vaccination of CY-treated mice with C. albicans ribosomes, with or without addition of incomplete Freund's adjuvant, led to a partial protection against a lethal IP or IV challenge with live yeasts. These results indicate the possible effectiveness of ribosomal vaccination in protecting the compromised host against experimental candidiasis.

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Citations

Apr 2, 2009·Dermatologic Therapy·Kelly ConnerStephen K Tyring
Aug 16, 2011·International Journal of Antimicrobial Agents·R SemisE Segal
Jan 1, 1987·Critical Reviews in Microbiology·E Segal
Dec 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·E SegalL Barr-Nea
Jun 20, 2020·Cellular Microbiology·Gabriele VargasLeonardo Nimrichter

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