Experimental validation for quantitative protein network models

Current Opinion in Biotechnology
Satoshi Nishizuka, Brett Spurrier

Abstract

Cellular responses are the consequence of complex reactions of protein networks. The complexity should ultimately be described by a set of formulas in a quantitative fashion, in which each formula defines the reactions in response to given types of input. However, testing these formulas has not been a simple task because of the lack of appropriate means for experimental validation. 'Reverse-phase' lysate microarrays have been proved to be powerful for such requirements and thus can be a good resource for providing an experimental reference point for the theoretical biology of protein networks.

References

Jul 1, 1988·Computer Methods and Programs in Biomedicine·V GuardabassoD Rodbard
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M KringsteinH M Blau
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Lev Bar-OrM Oren
Jul 20, 2002·Current Opinion in Pharmacology·John N Weinstein
Jul 31, 2002·The Lancet Oncology·Shi-Ming TuChristopher J Logothetis
Sep 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Isabel González-GarcíaJosé Costa
Sep 16, 2003·Proteomics·Paul C HerrmannEmanuel F Petricoin
Oct 11, 2003·Trends in Genetics : TIG·Hui GeMarc Vidal
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Satoshi NishizukaJohn N Weinstein
Jan 20, 2004·Nature Genetics·Galit LahavUri Alon
Jul 21, 2004·Progress in Biophysics and Molecular Biology·Herbert M Sauro, Boris N Kholodenko
Nov 24, 2004·Nature Medicine·Steven M ChanPaul J Utz
Jan 14, 2005·Bioinformatics·Cristian MirceanWei Zhang
Mar 29, 2005·Nature Cell Biology·Satoru SasagawaShinya Kuroda
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian GulmannAndrew L Feldman
Feb 17, 2006·Nature Reviews. Molecular Cell Biology·Boris N Kholodenko
Apr 29, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Satoshi Nishizuka
Jun 15, 2006·Molecular Systems Biology·Naama Geva-ZatorskyUri Alon
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·John G AlbeckSuzanne Gaudet
Feb 15, 2007·Molecular Systems Biology·Thomas HaberichterSteven F Dowdy
Feb 20, 2007·Proteomics·Christian LoebkeUlrike Korf
Feb 27, 2007·Nature Genetics·Ido AmitYosef Yarden
Mar 7, 2007·Molecular Cancer Therapeutics·Uma T ShankavaramJohn N Weinstein
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ozgür SahinDorit Arlt
Jun 15, 2007·Journal of Proteome Research·Kanchana Natarajan MendesWei Zhang
Jun 30, 2007·Bioinformatics·Jianhua HuGordon B Mills
Jul 10, 2007·Cancer Research·Sundhar RamalingamSatoshi Nishizuka
Aug 22, 2007·Proteomics·Brett SpurrierSatoshi Nishizuka

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Citations

Nov 1, 2008·Nature Protocols·Brett SpurrierSatoshi Nishizuka
Jan 30, 2016·Drug Metabolism and Pharmacokinetics·Satoshi S Nishizuka, Gordon B Mills
Mar 29, 2011·Journal of Theoretical Biology·D NapoletaniE Petricoin
Aug 3, 2010·Journal of Neuroscience Methods·Andrea B GyorgyDenes V Agoston
Dec 17, 2014·PloS One·Poorvi KaushikChris Sander

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