Experimental validation of a coincidence time resolution metric including depth-of-interaction bias for TOF-PET.

Physics in Medicine and Biology
Francis Loignon-HouleRoger Lecomte

Abstract

Depth-of-interaction (DOI) variability of annihilation photons is known to be a source of coincidence time resolution (CTR) degradation for fast time-of-flight-positron emission tomography detectors. An analytical model was recently proposed to explicitly include the DOI time bias separately from variance-related statistical factors, such as scintillation photon emission and photosensor jitter, in the CTR evaluation. In the present work, an experimental validation of this new model is provided. An unconventional signal readout configuration was used to magnify the DOI bias with 20 mm long LYSO:Ce crystals. In a head-to-head orientation of the crystals, simulations performed using the metric with DOI bias exhibited a much better agreement (within 21 ps) with the experimentally measured CTR of 413 ± 8 ps full-width at half maximum, whereas simulations without DOI bias underestimated the CTR by 138 ps. The metric including DOI bias was shown to also be effective at predicting the CTR of the head-to-head setup (without DOI information) using data from a DOI-collimated experimental setup (with partial DOI information). With the development of new low-variance ultra-fast detectors, the DOI timing blur will become increasingly importa...Continue Reading

References

Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joel S KarpGerd Muehllehner
Dec 25, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Roger Lecomte
Jan 14, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Maurizio Conti
Mar 12, 2013·Physics in Medicine and Biology·Emilie Roncali, Simon R Cherry
May 31, 2014·PloS One·Mark S BrownIoannis Papakonstantinou
Feb 18, 2016·EJNMMI Physics·S VandenbergheJ S Karp
Jan 5, 2017·Physics in Medicine and Biology·Francis Loignon-HouleRoger Lecomte
Apr 12, 2017·Physics in Medicine and Biology·Emilie RoncaliSimon R Cherry
Apr 18, 2018·Physics in Medicine and Biology·Michel DefriseJohan Nuyts
Nov 25, 2018·Optics Express·Lenka ProcházkováMartin Nikl
Jan 11, 2019·Physics in Medicine and Biology·Stefan GundackerPaul Lecoq
Feb 1, 2019·Physics in Medicine and Biology·Maxime ToussaintRoger Lecomte
Jun 27, 2019·Physics in Medicine and Biology·M PizzichemiE Auffray

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Citations

Mar 13, 2021·Physics in Medicine and Biology·Dennis R Schaart
Aug 26, 2021·Physics in Medicine and Biology·Nicolaus KratochwilEtiennette Auffray

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