Experimental validation of a T2rho transverse relaxation model using LASER and CPMG acquisitions

Journal of Magnetic Resonance
Simona NikolovaRobert Bartha

Abstract

The transverse relaxation rate (R2=1/T2) of many biological tissues are altered by endogenous magnetized particles (i.e., ferritin, deoxyhemoglobin), and may be sensitive to the pathological progression of neurodegenerative disorders associated with altered brain-iron stores. R2 measurements using Carr-Purcell-Meiboom-Gill (CPMG) acquisitions are sensitive to the refocusing pulse interval (2taucp), and have been modeled as a chemical exchange (CE) process, while R2 measurements using a localization by adiabatic selective refocusing (LASER) sequence have an additional relaxation rate contribution that has been modeled as a R2rho process. However, no direct comparison of the R2 measured using these two sequences has been described for a controlled phantom model of magnetized particles. The three main objectives of this study were: (1) to compare the accuracy of R2 relaxation rate predictions from the CE model with experimental data acquired using a conventional CPMG sequence, (2) to compare R2 estimates obtained using LASER and CPMG acquisitions, and (3) to determine whether the CE model, modified to account for R2rho relaxation, adequately describes the R2 measured by LASER for a full range of taucp values. In all cases, our ana...Continue Reading

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Citations

Dec 7, 2007·Magnetic Resonance Imaging·Simona NikolovaRobert Bartha
Jun 30, 2007·Journal of Magnetic Resonance·Ziqi Sun, Robert Bartha
Dec 7, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Shalom MichaeliPaul Tuite

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