Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including "ghosts," nucleic acid-free bacterial rods.

Infection and Immunity
H I Huppertz, J Heesemann

Abstract

Yersinia enterocolitica O:3 was maintained in primary cultures of human synovial cells for 6 weeks as cultivable organisms and thereafter for 2 more weeks as antigen aggregates containing specific lipopolysaccharides (LPS). Some seemingly intact bacteria were "ghosts," bacterial rods possessing LPS but not DNA. The prolonged persistence of yersiniae, and consequently of Yersinia antigens, in synovial cells may be the cause of the maintenance of the inflammatory host responses in the joints of patients with reactive arthritis due to Yersinia infection.

References

Feb 1, 1991·The Journal of General Virology·H I Huppertz, J K Chantler
Feb 1, 1991·Annals of the Rheumatic Diseases·R Merilahti-PaloA Toivanen
Jan 26, 1989·The New England Journal of Medicine·K GranforsA Toivanen
Apr 1, 1988·Arthritis and Rheumatism·M Leirisalo-Repo, H Suoranta
Jun 1, 1985·Annals of the Rheumatic Diseases·V V ValtonenP H Mäkelä
Dec 1, 1993·Infection and Immunity·M WuorelaK Granfors

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Citations

Jul 31, 1999·Cell Adhesion and Communication·H J GirschickH I Huppertz
Mar 11, 2016·Zeitschrift für Rheumatologie·H-I Huppertz
Apr 14, 2017·Immunology and Cell Biology·Katarzyna KasperkiewiczMaciej Cedzyński
Dec 21, 2000·Clinical and Experimental Immunology·M SchoppetH I Huppertz
Aug 6, 1999·FEMS Immunology and Medical Microbiology·N MarkovaK Veleva
Oct 10, 1998·The American Journal of the Medical Sciences·M Ikeda, D T Yu
Feb 3, 1999·Baillière's Clinical Rheumatology·L KoehlerA P Hudson

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