PMID: 9189055May 1, 1997Paper

Experimental Yersinia-triggered reactive arthritis: effect of a 3-week course of ciprofloxacin

British Journal of Rheumatology
Y ZhangP Toivanen

Abstract

Lewis rats were injected i.v. with live Yersinia enterocolitica, resulting in 1-2 weeks in an arthritis greatly resembling human reactive arthritis. Starting on day 3, 5, 10 or 13 after the bacterial inoculation, the rats were treated for 3 weeks with 20 mg/kg/day of ciprofloxacin. The development of arthritis was completely prevented if the antibiotic treatment was started on day 3. In a group of rats treated with ciprofloxacin from day 5 onwards, 2/14 rats already showed mild arthritis at the time when the treatment was started. Antibiotic treatment cured the arthritis of these rats as well as that of one additional individual in this group which developed arthritis. No later exacerbations occurred. If the antibiotic treatment was started on day 10 or 13, i.e. at the time of well-developed arthritis, no effect on arthritis was observed; rather, increased faecal excretion of Yersinia occurred following the antibiotic treatment. We conclude that experimental Yersinia reactive arthritis can be cured by antibiotics introduced at an early phase of arthritic development. Regarding acute human enterogenic arthritis, the decision on antibiotic treatment is not a straightforward matter. Our experimental results indicate that the earli...Continue Reading

Citations

Dec 22, 1999·Microbes and Infection·E J Bottone
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judy R ReesDuc J Vugia
Jun 30, 2000·Annals of the Rheumatic Diseases·T Yli-KerttulaA Toivanen
Jun 18, 2003·Annals of the Rheumatic Diseases·K LaasilaM Leirisalo-Repo
Aug 19, 2003·Annals of the Rheumatic Diseases·T Yli-KerttulaA Toivanen
Dec 21, 2000·Current Rheumatology Reports·M BrebanD Lamarque
Oct 25, 2011·Enfermedades infecciosas y microbiología clínica·Anna Fàbrega, Jordi Vila
Apr 26, 2008·Journal of the American Academy of Dermatology·Ines B Wu, Robert A Schwartz
Mar 15, 2003·Rheumatic Diseases Clinics of North America·Diana FloresLuis R Espinoza
May 16, 2017·Internal Medicine·Kazuya HondaKiyoshi Migita
Mar 21, 2000·Rheumatology·A Toivanen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.