Experimental Zika virus infection in Aedes aegypti : Susceptibility, transmission & co-infection with dengue & chikungunya viruses

The Indian Journal of Medical Research
D T MouryaMangala S Mavale

Abstract

There are reports about the susceptibility of Aedes mosquitoes to ZIKV from various countries, however, no such information is available from Indian sub-continent, although, high level of group cross-reactivity of ZIKV with other flaviviruses has been reported. During outbreak situations, many cases of Dengue (DEN) and Chikungunya (CHIK) are reported. In such scenario, vector mosquitoes are likely to get co-infection/secondary-infection with one or other virus. The present study was carried out to determine the susceptibility of Indian strain of Aedes aegypti to Zika virus (ZIKV) strain (MR-766) and the effect of co-infection/super-infection with either dengue virus (serotype-2) (DENV) or chikungunya virus (CHIKV) on ZIKV replication. Ae. aegypti mosquitoes used in this study were reared for many generations since 1980 at laboratory colony maintained at the ICMR-National Institute of Virology, Pune, India. Transmissibility of ZIKV from infected mosquitoes to suckling mice was also studied. Mosquitoes were experimentally infected with ZIKV and super-infected with either DENV or CHIKV via membrane-feeding route and incubated for 14 days at 28±2°C and humidity of 85±5 per cent. Replication of these viruses in mosquitoes was confir...Continue Reading

References

Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW

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Citations

Jan 23, 2019·PLoS Biology·Chantal B F VogelsNathan D Grubaugh
May 21, 2019·PLoS Neglected Tropical Diseases·Eric P CaragataLuciano A Moreira
Feb 6, 2021·The Journal of Infectious Diseases·Nilton Barnabé RodriguesNagila Francinete Costa Secundino
Oct 16, 2020·PLoS Neglected Tropical Diseases·Zetian LaiXiao-Guang Chen
Dec 3, 2021·PLoS Neglected Tropical Diseases·Larissa Fernandes-MatanoJosé Esteban Muñoz-Medina

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