DOI: 10.1101/512269Jan 4, 2019Paper

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

BioRxiv : the Preprint Server for Biology
Elisabetta IavaroneSean Lewis Hill

Abstract

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states including wakefulness and sleep. This property is reflected at the cellular level by the ability to generate action potentials in two distinct firing modes, called tonic firing and low-threshold bursting. Although the general properties of TC neurons are known, we still lack a detailed characterization of their morphological and electrical properties in the VB thalamus. The aim of this study was to build biophysically-detailed models of VB TC neurons explicitly constrained with experimental data from rats. We recorded the electrical activity of VB neurons (N = 49) and reconstructed morphologies in 3D (N = 50) by applying standardized protocols. After identifying distinct electrical types, we used a multi-objective optimization to fit single neuron electrical models (e-models), which yielded multiple solutions consistent with the experimental data. The models were tested for generalization using electrical stimuli and neuron morphologies not used during fitting. A local sensitivity ...Continue Reading

Related Concepts

Cerebral Cortex
Dendrites
Neurons
Sleep
Wakefulness
Peripheral
Three-dimensional
Morphological
Somatosensory Disorders
Analysis

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E E FanselowM A Nicolelis
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A Destexhe, Terrence J Sejnowski
© 2021 Meta ULC. All rights reserved