Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Camille Tessitore KingAlan C Spector

Abstract

Studies examining the effects of transection and regeneration of the glossopharyngeal (GL) and chorda tympani (CT) nerves on various taste-elicited behaviors in rats have demonstrated that the GL (but not the CT) nerve is essential for the maintenance of both an unconditioned protective reflex (gaping) and the neural activity observed in central gustatory structures in response to lingual application of a bitter substance. An unresolved issue, however, is whether recovery depends more on the taste nerve and the central circuits that it supplies and/or on the tongue receptor cell field being innervated. To address this question, we experimentally cross-wired these taste nerves, which, remarkably, can regenerate into parts of the tongue they normally do not innervate. We report that quinine-stimulated gaping behavior was fully restored, and neuronal activity, as assessed by Fos immunohistochemistry in the nucleus of the solitary tract and the parabrachial nucleus, was partially restored only if the posterior tongue (PT) taste receptor cell field was reinnervated; the particular taste nerve supplying the input was inconsequential to the recovery of function. Thus, PT taste receptor cells appear to play a privileged role in trigger...Continue Reading

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Citations

May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicole R Kinzeler, Susan P Travers
Jul 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yada TreesukosolAlan C Spector
Apr 9, 2010·Journal of Neurophysiology·Min Wang, Robert M Bradley
Dec 4, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Edward John DoyleMark A Varvares
Apr 22, 2015·Physiology & Behavior·Alan C Spector

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