PMID: 6407100Jan 1, 1983Paper

Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs

Scandinavian Journal of Rheumatology
H TörnkvistT S Lindholm

Abstract

This paper reports the effects of peroral administration of the two non-steroid anti-inflammatory drugs ibuprofen and flubiprofen on orthotopic and induced heterotopic bone. The treatment induced no effects on the mineral or hydroxyproline contents of femur compared with a control group. Nor could any generalized toxic effects of the treatment be detected with respect to bodyweights or serum values of calcium, phosphate or albumin. Treatment with the drugs was commenced one week before initiating the heterotopic bone formation by implanting pieces of demineralized bone matrix in the abdominal muscle of growing rats. A significant decrease in specific amounts of calcium and phosphate was noted in the induced new-formed bone 4 weeks after implantation, whereas no such effect was apparent 2 weeks after implantation.

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Citations

Jan 1, 1987·Archives of Orthopaedic and Trauma Surgery·L F SolheimN Langeland
Jun 1, 1995·The Journal of Arthroplasty·S D CookT D Brown
Dec 14, 2007·Journal of Neurosurgery. Spine·Julio UrrutiaFelipe Quezada
Aug 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·G ObeidX Wang
Sep 24, 2004·Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology·Yasemin Güneş, Geylan Işik
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M H HuoG E Friedlaender
Dec 1, 1993·The Australian and New Zealand Journal of Surgery·A J Thurston, N A Spry
Jun 25, 2002·Spinal Cord·A A van KuijkH J M van Kuppevelt
Dec 28, 1999·Clinical Orthopaedics and Related Research·C VielpeauC Hulet
Feb 1, 1985·Acta Orthopaedica Scandinavica·E ElmstedtH Törnkvist
Jan 26, 1999·Clinical Orthopaedics and Related Research·D J SchneiderV D Pellegrini
Jun 1, 1996·The Journal of Bone and Joint Surgery. American Volume·V D Pellegrini, S J Gregoritch
Jan 1, 1985·Scandinavian Journal of Rheumatology·H TörnkvistO S Nilsson
Aug 1, 1991·Acta Orthopaedica Scandinavica·P AdolphsonN Dalén

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