Experimentally induced hypo- and hyper-thyroidism influence on the antioxidant defence system in adult rat testis

Andrologia
S ChoudhuryM M Mishro

Abstract

The objective of the present experiment was to study the effect of thyroid hormone on the antioxidant defence system of rat testis. Hypothyroidism induced in rats by 6-n propyl 2-thiouracil (PTU) treatment resulted in a reduction in body weight, seminal vesicle and ventral prostate gland. A further decrease in the weight of seminal vesicle was recorded following administration of T3 to hypothyroid rats. The oxidative stress parameters such as hydrogen peroxide and protein carbonyl content increased in the crude homogenate of testis of hypothyroid rats. T3 administration to hypothyroid rats resulted in no further change in the hydrogen peroxide level but the protein carbonyl content further elevated in the crude homogenate of testis. No significant change was observed in the endogenous lipid peroxidation level of the crude homogenate of testis whereas the FeSO4/ascorbic acid induced lipid peroxidation level decreased in hypothyroid rats and did not change further by T3 administration. Although the reduced glutathione level in the crude homogenate of testis did not change following hypothyroidism, oxidized glutathione level increased. The reduced and oxidized glutathione level decreased and increased, respectively following T3 ad...Continue Reading

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