Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of inter optode spacing

Advances in Experimental Medicine and Biology
P van der ZeeE O Reynolds

Abstract

The Differential Pathlength Factor (DPF) has been measured for several different tissues. The results showed that the DPF varied with the type of tissue studied, and in the case of the adult calf with sex. However, the DPF for all tissues studied was constant once the inter optode spacing exceeded 2.5 cm. Thus, measurements can be made by NIR spectroscopy at a range of inter optode spacings, and a single DPF used in the calculation of chromophore concentration. The results also showed that the major source of error in the DPF lay in the measurement of the inter optode spacing. To improve accuracy, two options are possible. Firstly, some means of continuous measurement of inter optode spacing could be incorporated in the NIR instrumentation. The better alternative would be an instrument incorporating a method of directly measuring the optical pathlength at each wavelength. This could be done either by time of flight measurement, or if it can be validated, by phase shift measurement.

Citations

Jan 17, 1996·Annals of the New York Academy of Sciences·C HockA Villringer
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H R HeekerenA Villringer
May 1, 1997·Stroke; a Journal of Cerebral Circulation·J LamP J Kirkpatrick
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W J Levy
Jul 1, 1997·Medical & Biological Engineering & Computing·C W Yoxall, A M Weindling
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wolfgang M KueblerA E Goetz
Jul 17, 1998·Pediatric Research·S P WardleA M Weindling
Mar 24, 1999·Pediatric Research·S P WardleA M Weindling
Apr 12, 2000·Acta Physiologica Scandinavica·Robert Boushel, C A Piantadosi
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·M P HarmsJ J van Lieshout
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R WenzelA Villringer
Feb 7, 2001·Pediatric Research·P ZaramellaL Chiandetti
Jul 13, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Harvey L EdmondsErle H Austin
Dec 1, 2004·Journal of Biomedical Optics·Subhadra SrinivasanKeith D Paulsen
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hiroshi MitsutaToshimasa Asahara
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira KoikeTadanori Aizawa
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sarah-Jane C LusinaA William Sheel
Apr 3, 2008·Developmental Neurobiology·Yasuyo Minagawa-KawaiEmmanuel Dupoux
Jul 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Duraisamy BalaguruKaren Norton
Jun 28, 2011·Neonatology·Nina TaxBerndt Urlesberger
Mar 13, 2012·European Journal of Applied Physiology·Stylianos N KounalakisIgor B Mekjavic
Mar 9, 2013·Medicine and Science in Sports and Exercise·Lotte JanssensSimon Brumagne
Nov 2, 2014·Journal of Innovative Optical Health Sciences·Meryem A YücelDavid A Boas
Feb 12, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David CurtelinJose A L Calbet
Jan 24, 2018·Biomedical Optics Express·Stanislaw WojtkiewiczHamid Dehghani
Mar 29, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryota Asahara, Kanji Matsukawa
Jun 13, 2019·European Journal of Applied Physiology·Sarah J WillisGrégoire P Millet
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C HockA Villringer
May 23, 1998·Acta Physiologica Scandinavica·P MadsenN H Secher
Jan 1, 1995·European Journal of Pediatrics·A D Edwards
Dec 1, 1995·Journal of Neurosurgery·P J KirkpatrickJ D Pickard
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J S Wyatt
Jun 5, 2002·Physics in Medicine and Biology·L Martyn KlassenRavi S Menon
Apr 8, 2003·Journal of Applied Physiology·Darren S DeLoreyDonald H Paterson
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Osamu NagayamaTadanori Aizawa
Jan 26, 2008·Journal of Applied Physiology·Jordan A GuenetteRobert Boushel
Nov 23, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Andrew W SubudhiRobert C Roach
Mar 22, 2008·Clinical Physiology and Functional Imaging·Eiji YamadaSusumu Itoh
Aug 28, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira KoikeTadanori Aizawa
May 5, 2007·European Journal of Applied Physiology·Osamu YanagisawaHideyuki Takahashi
Oct 4, 2008·The Journal of Physiology·Ioannis VogiatzisSpyros Zakynthinos
Oct 4, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira KoikeTadanori Aizawa
May 25, 2012·Cephalalgia : an International Journal of Headache·Louise V CouttsArnold J Wilkins
Sep 17, 2011·Journal of Applied Physiology·Andrew W SubudhiRobert C Roach
Feb 11, 2014·European Journal of Applied Physiology·Nicolas BourdillonBengt Kayser
Sep 18, 2013·European Journal of Applied Physiology·Taiki MiyazawaShigehiko Ogoh
Sep 5, 2015·Cognitive, Affective & Behavioral Neuroscience·Gavin D Tempest, Gaynor Parfitt
Apr 19, 2017·Pediatric Research·Chuen Wai LeeTopun Austin
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T WolfU Dirnagl
Jun 1, 1995·British Journal of Obstetrics and Gynaecology·C J AldrichE O Reynolds
Sep 29, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T OhataH Matsuda
Jan 1, 1995·British Journal of Obstetrics and Gynaecology·C J AldrichE O Reynolds
Feb 13, 2001·Journal of Applied Physiology·M C Van BeekveltB G Van Engelen
Oct 23, 2003·Psychophysiology·Jeremy C Hebden
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·S ShibataK Dohi
Aug 14, 2003·Clinical Physiology and Functional Imaging·Koichi KuriharaAsao Kobayashi
Mar 29, 2000·Clinical Physiology·P L MadsenP Christiansen
May 4, 2010·Physics in Medicine and Biology·T E J NoponenP T Meriläinen
Jun 10, 2010·Physics in Medicine and Biology·F Orihuela-EspinaG Z Yang
Feb 1, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tieh-Cheng FuJong-Shyan Wang
Jun 25, 2005·Journal of Oral Rehabilitation·K OkadaN Inoue
May 29, 2010·Journal of Applied Physiology·Dimitris AthanasopoulosIoannis Vogiatzis
Apr 14, 2007·Journal of Applied Physiology·Andrew W SubudhiRobert C Roach
May 2, 2009·Journal of Biomedical Optics·Meir Nitzan, Shlomo Engelberg
May 19, 2011·Journal of Sports Sciences·Ioannis VogiatzisDimitrios Athanasopoulos
Jun 7, 2014·Journal of Applied Physiology·Zafeiris LouvarisSpyros Zakynthinos
Jul 5, 2016·Frontiers in Human Neuroscience·Muhammad A KamranMyung Yung Jeong
Jul 1, 2010·Reports on Progress in Physics·T DurduranA G Yodh
Jun 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C R NewtonR J Traystman
Apr 1, 1995·Annals of Neurology·A J du PlessisJ J Volpe
May 1, 1995·Journal of Neurosurgery·P J KirkpatrickJ D Pickard
Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J Van de VenH Folgering
Sep 24, 2004·Physiological Measurement·E SzufladowiczF Walczak
Jul 1, 1996·Perfusion·M I AliK M Taylor
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M TamuraF Okada
Jan 13, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Naoki ShimizuKatsuyuki Miyasaka
Nov 2, 2011·Experimental Physiology·Taiki MiyazawaShigehiko Ogoh
Jul 3, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Willem P de BoodeK D Liem
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ioannis VogiatzisSpyros Zakynthinos
Dec 1, 1995·Stroke; a Journal of Cerebral Circulation·P SmielewskiM Czosnyka
Mar 1, 1995·Journal of Clinical Monitoring·D A BenaronB Chance
May 3, 2005·Biomedical Engineering Online·Alper BozkurtBanu Onaral
Sep 21, 2007·European Journal of Applied Physiology·Thomas RuppPerrey Stephane
Apr 1, 1993·Physics in Medicine and Biology·M FirbankD T Delpy
May 6, 2010·The Review of Scientific Instruments·Syed Mahfuzul AzizRuth Marshall
May 20, 2009·The Journal of Physiology·Ioannis VogiatzisSpyros Zakynthinos
Jan 20, 2009·Journal of Applied Physiology·Andrew W SubudhiRobert C Roach
Apr 1, 1999·Journal of Biomedical Optics·P G Al-RawiP J Kirkpatrick
Mar 7, 2021·Sensors·María Roldán, Panayiotis A Kyriacou

Related Concepts

Use-Effectiveness
Forearm
Head
Neonatal Prematurity
Infrared Rays
Leg
Dioxygen
Scattering, Radiation
Infrared Spectrophotometry
Photonics

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.