PMID: 7541385Jul 1, 1995Paper

Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S KennedyK P Ponder

Abstract

One hypothesis is that postnatal liver growth involves replication of mature hepatocytes, which have an unlimited proliferative potential. An alternative viewpoint is that only certain periportal cells can replicate extensively and that daughter cells stream slowly from the periportal to the pericentral region of the liver. Transgenic mice expressing the beta-galactosidase (beta-gal) gene from the human alpha 1 antitrypsin promoter were used to examine the proliferative potential of hepatocytes. Surprisingly, only 10% of hepatocytes in two different transgenic lines stain blue with X-gal. In neonatal animals, singlets or doublets of expressing cells are randomly scattered throughout the liver. Although the overall frequency of blue cells is similar in older animals, these cells are present in much larger clusters, suggesting that individual expressing cells have replicated to form a clonally derived cluster. Expression patterns are not altered by the administration of an acute phase stimulus or by the performance a partial hepatectomy, suggesting that the expression state cannot be easily altered, and making it more likely that the expression state is indeed fixed. These results suggest that the clusters of blue cells are clona...Continue Reading

References

Jul 10, 1992·Cell·A Bird
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K P PonderS L Woo
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K A RothJ I Gordon
Feb 1, 1990·Current Opinion in Cell Biology·L M Reid
Aug 11, 1989·Cell·F AntequeraA P Bird
Apr 1, 1989·The Journal of Clinical Investigation·J A CarlsonS L Woo
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G P NolanL A Herzenberg
Sep 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·H J HeinigerF Cantelmo
Mar 1, 1968·The Journal of Cell Biology·J I Fabrikant
Nov 1, 1982·Seminars in Liver Disease·H L Sharp
Dec 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·N FaustoN Shiojiri

❮ Previous
Next ❯

Citations

Mar 1, 2008·Hepatology International·William S MasonAllison R Jilbert
Aug 9, 2001·Artificial Organs·H O Jauregui
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RosenbergS Sell
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Isabelle AuvigneNicolas Ferry
Jan 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·William S MasonJesse Summers
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M AlisonC Sarraf
Sep 10, 1998·Genes & Development·S NewlandsE C Hardeman
Nov 23, 2011·The Journal of Clinical Investigation·Yann MalatoHolger Willenbring
Nov 23, 2011·The Journal of Clinical Investigation·Joshua R Friedman, Klaus H Kaestner
Jun 29, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Benjamin M StutchfieldStephen J Wigmore
May 19, 2001·Pathology·C J Vessey, P M de la Hall
Mar 12, 2015·Virology·Christoph Seeger, William S Mason
May 5, 2017·Viruses·Patrick T F KennedyWilliam S Mason
Mar 13, 2008·The Biochemical Journal·Karen WallaceMatthew C Wright
Apr 7, 2011·Nature Reviews. Genetics·Mark A Kay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.