Expert assessment on volumetric laser endomicroscopy full scans in Barrett's esophagus patients with or without high grade dysplasia or early cancer.

Endoscopy
Maarten StruyvenbergJacques J Bergman

Abstract

 Volumetric laser endomicroscopy (VLE) allows for near-microscopic imaging of the superficial esophageal wall and may improve detection of early neoplasia in Barrett's esophagus (BE). Interpretation of a 6-cm long, circumferential VLE "full scan" may however be challenging for endoscopists. We aimed to evaluate the accuracy of VLE experts in correctly diagnosing VLE full scans of early neoplasia and non-dysplastic BE (NDBE).  29 VLE full scan videos (15 neoplastic and 14 NDBE) were randomly evaluated by 12 VLE experts using a web-based module. Experts were blinded to the endoscopic BE images and histology. The 15 neoplastic cases contained a subtle endoscopically visible lesion, which on endoscopic resection showed high grade dysplasia or cancer. NDBE cases had no visible lesions and an absence of dysplasia in all biopsies. VLE videos were first scored as "neoplastic" or "NDBE." If neoplastic, assessors located the area most suspicious for neoplasia. Primary outcome was the performance of VLE experts in differentiating between non-dysplastic and neoplastic full scan videos, calculated by accuracy, sensitivity, and specificity. Secondary outcomes included correct location of neoplasia, interobserver agreement, and level of confi...Continue Reading

References

Feb 1, 2005·Archives of Pathology & Laboratory Medicine·Elizabeth R Tschanz
Oct 2, 2013·Gastrointestinal Endoscopy·Louisa G GordonDavid I Watson
Oct 30, 2013·Endoscopy·Lorenza Alvarez HerreroJacques G H M Bergman
Nov 4, 2015·The American Journal of Gastroenterology·Nicholas J ShaheenUNKNOWN American College of Gastroenterology
Jun 23, 2016·Digestive Diseases·Kamar BelghaziRoos E Pouw
May 1, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M S SmithK Chang

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Citations

Jan 28, 2022·Digestive Diseases and Sciences·Kengyeh K ChuAdam Wax

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