Expert opinion on emerging urate-lowering therapies

Expert Opinion on Emerging Drugs
Lisa K StampJasvinder A Singh

Abstract

There has been a resurgence in gout therapeutics in the last decade, not only for the management of gout flares, but also for the treatment of hyperuricemia. This editorial summarizes new, emerging therapies for people with gout. Areas covered: We review several new therapies for gout, including those that are focused on lowering serum urate (levotofisopam, ulodesine, verinurad, merbarone, KUX-1151, UR-1102, FYU-981, SEL-212), or treating gout flares (canakinumab, bucillamine) or both (arhalofenate, diacerein). Expert opinion: Among therapies with both urate lowering and anti-inflammatory action, arhalofenate seems promising, but more data are needed. Examining therapies aimed at treating gout flares [anti-inflammatory action], bucillamine has some potential, but more data and Phase III studies are needed, to better understand its efficacy and safety. Among the urate-lowering therapies (ULTs), verinurad seems to be the most promising, while levotofisopam and ulodesine require more data. A uricase-replacement therapy with improved immune reaction (SLE-212) is in a Phase II trial. A number of ULTs including KUX-1151, UR-1102 and FYU-981 are in early development and more will be known once initial data and studies are published.

References

Jun 1, 1989·Metabolism: Clinical and Experimental·R P WarrellC W Young
Dec 13, 2005·The New England Journal of Medicine·Michael A BeckerNancy Joseph-Ridge
May 29, 2007·Arthritis and Rheumatism·Jasvinder A SinghSteven M Asch
Feb 6, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elena Panova, Graeme Jones
Jan 27, 2016·The Pharmacogenomics Journal·R L RobertsL K Stamp
Mar 19, 2016·Arthritis & Rheumatology·Jeffrey PoileyUNKNOWN Arhalofenate Flare Study Investigators
Jul 28, 2016·Annals of the Rheumatic Diseases·P RichetteT Bardin
Dec 10, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Tetsuya TaniguchiTakashi Iwanaga

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Citations

Mar 12, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alessandro MalobertiUNKNOWN Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
Nov 2, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Viola KlückLeo A B Joosten
Jul 11, 2020·Kidney International·Claudio PonticelliGabriella Moroni
Oct 29, 2021·Journal of Biomedical Nanotechnology·Tianjiao HanHongzheng Fu

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