Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

Expert Opinion on Drug Metabolism & Toxicology
Fabio FacchinettiVittorio Unfer

Abstract

Introduction: This Experts' opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM).Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients.Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or ...Continue Reading

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Citations

Jun 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Antonio Simone LaganàVittorio Unfer
Sep 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Fabio FacchinettiUNKNOWN Experts Group on Inositol in Basic and Clinical Research
Jun 17, 2020·Expert Opinion on Investigational Drugs·Luigi Della CortePierluigi Giampaolino
Oct 2, 2020·International Journal of Molecular Sciences·Vittorio UnferMariano Bizzarri
Oct 20, 2020·Expert Opinion on Drug Safety·Manuel Luque-RamírezHéctor F Escobar-Morreale
Oct 24, 2020·Systems Biology in Reproductive Medicine·Marta SantoroGiampiero Russo
Nov 24, 2020·Women's Health·Aigul SafiSvetlana Kalinchenko
Feb 13, 2021·Journal of Clinical Medicine·Fahimeh Ramezani TehraniSamira Behboudi-Gandevani
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zdravko Kamenov, Antoaneta Gateva
Dec 23, 2020·International Journal of Molecular Sciences·Małgorzata SzczukoMaciej Ziętek
Jun 5, 2021·Journal of Human Reproductive Sciences·Meryem Kuru PekcanYaprak Engin-Ustun
Jun 3, 2021·International Journal of Molecular Sciences·Arturo BevilacquaCarla Tatone
Jun 26, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mariano BizzarriAntonio Simone Laganà

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