Expiratory activation of abdominal muscle is associated with improved respiratory stability and an increase in minute ventilation in REM epochs of adult rats

Journal of Applied Physiology
Colin G Andrews, Silvia Pagliardini

Abstract

Breathing is more vulnerable to apneas and irregular breathing patterns during rapid eye movement (REM) sleep in both humans and rodents. We previously reported that robust and recurrent recruitment of expiratory abdominal (ABD) muscle activity is present in rats during REM epochs despite ongoing REM-induced muscle atonia in skeletal musculature. To develop a further understanding of the characteristics of ABD recruitment during REM epochs and their relationship with breathing patterns and irregularities, we sought to compare REM epochs that displayed ABD muscle recruitment with those that did not, within the same rats. Specifically, we investigated respiratory characteristics that preceded and followed recruitment. We hypothesized that ABD muscle recruitment would be likely to occur following respiratory irregularities and would subsequently contribute to respiratory stability and the maintenance of good ventilation following recruitment. Our data demonstrate that epochs of REM sleep containing ABD recruitments (REM(ABD+)) were characterized by increased respiratory rate variability and increased presence of spontaneous brief central apneas. Within these epochs, respiratory events that displayed ABD muscle activation were prec...Continue Reading

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Citations

Nov 4, 2016·The Journal of Physiology·Rozlyn C T BoutinSilvia Pagliardini
Aug 5, 2017·The Journal of Physiology·Isabela P LeirãoGlauber S F da Silva
Aug 24, 2017·The Journal of Physiology·Ken D O'Halloran
Feb 13, 2019·The Journal of Physiology·Melina P da SilvaBenedito H Machado
Oct 27, 2017·Journal of Neurophysiology·William H BarnettDaniel B Zoccal
May 10, 2018·Nature Reviews. Neuroscience·Christopher A Del NegroJack L Feldman
Jun 27, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Josiane N SilvaAna C Takakura
Sep 12, 2020·Pflügers Archiv : European journal of physiology·Isabela P LeirãoGlauber S F da Silva
Aug 4, 2021·Respiratory Physiology & Neurobiology·Bolival A Mendonça-JuniorDaniel B Zoccal

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