Expiratory glottic widening in asthmatic subjects during exercise-induced bronchoconstriction

The American Review of Respiratory Disease
I RubinsteinV Hoffstein

Abstract

Glottic caliber is modulated in a way that optimizes the airway resistance and the work of breathing. The midexpiratory glottic narrowing that normally occurs during tidal breathing is enhanced during histamine- or methacholine-induced airway narrowing. Exercise is associated with increased ventilatory demand and midexpiratory glottic widening in healthy subjects. However, the relative contribution of glottic aperture to airflow limitation during exercise-induced asthma is unknown. Consequently, we used the acoustic reflection technique to test whether a decrease in midexpiratory glottic size occurred also during exercise-induced bronchoconstriction in seven asthmatic subjects. Exercise resulted in a 38 +/- 16% (SD) fall in FEV1 from the baseline value (p less than 0.001) and a significant increase in midexpiratory glottic cross-sectional area from 1.89 +/- 0.45 cm2 before to 2.36 +/- 0.71 cm2 during bronchoconstriction (p less than 0.05). This midexpiratory glottic widening was also associated with increased tidal flow rates. We conclude that in marked contrast to airway obstruction induced by histamine or methacholine, exercise-induced asthma is associated with midexpiratory glottic widening, which occurs concomitantly with a...Continue Reading

References

Jul 1, 1993·Respiratory Medicine·S Godfrey, E Bar-Yishay
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Related Concepts

Histamine Measurement
Asthma, Exercise-Induced
Bronchospasm, Exercise-Induced
Expiration, Function
Rima Glottidis Structure
Airway Resistance
Bronchoconstriction
Asthma
Airflow
Work of Breathing

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