Expirograms of O2, CO2 and intravenously infused C2H2 and Freon-22 during panting in dogs

Respiration Physiology
I SipinkováJ Piiper

Abstract

To study pulmonary gas transport in panting, expirograms of several inert and respiratory gases were simultaneously measured in panting dogs. The experiments were performed on 5 conscious dogs (mean body weight 34.4 kg) provided with a chronic tracheostomy. Panting at a mean frequency of 312/min (5.2 Hz) was induced by elevated room temperature (mean 28.1 degrees C). Isotonic saline equilibrated with 50% acetylene and 50% Freon-22 was infused intravenously at a constant rate (4 ml/min). Fractional concentrations in the tracheostomy tube were measured by a respiratory mass spectrometer, using a special sampling system designed for quasi-continuous analysis of rapidly changing gas concentrations. Air flow was monitored by an ultrasonic transit-time flowmeter. A tracing of expired gas concentrations versus expired volume showed no alveolar plateau, displaying a steep increase of Freon-22, acetylene and CO2 (decrease of O2) up to the onset of inspiration. The small but statistically highly significant differences between the expirograms of CO2 and O2, and of Freon-22 and acetylene, could be qualitatively explained by ventilation-perfusion inequalities with sequential emptying, by Taylor dispersion and by reversible solution in airw...Continue Reading

References

Oct 1, 1990·Respiration Physiology·G HahnJ Piiper
Jul 1, 1989·Respiration Physiology·M MeyerJ Piiper
Dec 1, 1982·Respiration Physiology·W R de VriesA Zwart
Aug 1, 1984·Respiration Physiology·H K Chang, A Harf

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Oct 1, 1990·Respiration Physiology·G HahnJ Piiper

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