Explaining event-related fields by a mechanistic model encapsulating the anatomical structure of auditory cortex

Biological cybernetics
Aida HajizadehReinhard König

Abstract

Event-related fields of the magnetoencephalogram are triggered by sensory stimuli and appear as a series of waves extending hundreds of milliseconds after stimulus onset. They reflect the processing of the stimulus in cortex and have a highly subject-specific morphology. However, we still have an incomplete picture of how event-related fields are generated, what the various waves signify, and why they are so subject-specific. Here, we focus on this problem through the lens of a computational model which describes auditory cortex in terms of interconnected cortical columns as part of hierarchically placed fields of the core, belt, and parabelt areas. We develop an analytical approach arriving at solutions to the system dynamics in terms of normal modes: damped harmonic oscillators emerging out of the coupled excitation and inhibition in the system. Each normal mode is a global feature which depends on the anatomical structure of the entire auditory cortex. Further, normal modes are fundamental dynamical building blocks, in that the activity of each cortical column represents a combination of all normal modes. This approach allows us to replicate a typical auditory event-related response as a weighted sum of the single-column act...Continue Reading

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Sep 11, 2021·Scientific Reports·Natacha Vanattou-SaïfoudineGiacomo Indiveri

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