Explaining racial differences in prostate cancer in the United States: sociology or biology?

The Prostate
Stephen J Freedland, William B Isaacs

Abstract

Black men in the United States have the highest incidence and mortality from prostate cancer in the world. Even after adjusting for stage at diagnosis, black men have higher mortality rates than white men. Multiple reasons have been postulated to explain these findings including access to care, attitudes about care, socioeconomic and education differences, differences in type and aggressiveness of treatment, dietary, and genetic differences. While each reason may contribute to the higher incidence or higher mortality, likely combinations of reasons will best explain all the findings. Racial differences in socioeconomic status have been well established and we review the significance of these findings in relationship to prostate cancer. Also, with recent advances in the understanding of genetic variation in the human genome, in general, and in the genes involved in pathways relevant to prostate cancer biology, in particular, a number of genes with alleles which differ in frequency between black and white men have been proposed as a genetic cause or contributor to the increased prostate cancer risk in black men. However, the clinical significance of these genetic differences is not fully known. Finally, we conclude with some thou...Continue Reading

References

Oct 4, 1995·Journal of the National Cancer Institute·Y WangW D Heston
Oct 25, 1995·JAMA : the Journal of the American Medical Association·J W MoulD G McLeod
Oct 6, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Aug 1, 1996·The New England Journal of Medicine·T O MorganJ W Moul
Jan 15, 1997·Journal of the National Cancer Institute·S A InglesG A Coetzee
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·F S vom SaalW V Welshons
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E GiovannucciP W Kantoff
Jan 9, 1998·International Journal of Radiation Oncology, Biology, Physics·O W Brawley
May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L BennettO Sartor
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsC A Pettaway
Mar 10, 1999·Journal of the National Cancer Institute·L N KolonelR V Cooney
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanP T Scardino
Aug 19, 1999·Journal of the National Cancer Institute·R G RoetzheimJ P Krischer
Oct 19, 1999·Journal of the American Dietetic Association·B ThompsonN Cohen
Jun 16, 2000·Annals of Epidemiology·G HowardG L Burke
Oct 4, 2000·JAMA : the Journal of the American Medical Association·A H MokdadJ P Koplan
Dec 21, 2000·Journal of the National Cancer Institute·E A PlatzE Giovannucci
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P P ConnellS Vijayakumar

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Citations

Dec 4, 2008·Journal of Immigrant and Minority Health·Folakemi T OdedinaNagi Kumar
May 1, 2012·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Brian M RiversPaul B Jacobsen
Jun 1, 2005·European Urology·Stéphane MallickLuc Multigner
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lionel L BañezStephen J Freedland
Oct 1, 2008·Philosophy, Ethics, and Humanities in Medicine : PEHM·Mark S Moller
Oct 14, 2011·Infectious Agents and Cancer·R Renee ReamsClayton Yates
Apr 12, 2011·Annals of Surgical Oncology·Karen Kadela CollinsDonna B Jeffe
Jul 31, 2013·International Journal of Molecular Sciences·James FarrellShiv Srivastava
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew L FreedmanDavid Reich
Jan 17, 2008·World Journal of Surgery·Caprice C GreenbergSteven C Stain
Nov 23, 2013·The American Journal of Medicine·Tisheeka Graham-SteedJohn Concato
Mar 20, 2010·The Journal of Urology·Daniel M MoreiraStephen J Freedland
Jan 6, 2009·Urology·David F PensonLucien L Abenhaim
May 1, 2007·Current Opinion in Genetics & Development·Michael F Seldin
May 1, 2007·European Urology·Vincent RaveryLaurent Boccon-Gibod
Mar 21, 2007·European Urology·Yoav Ben-ShlomoUNKNOWN PROCESS study group
May 10, 2005·The Prostate·Christopher HaqqGustavo Ayala
May 3, 2008·International Journal of Cancer. Journal International Du Cancer·Simon EvansYoav Ben-Shlomo
May 30, 2013·BJU International·Andreas BeckerMaxine Sun
Apr 14, 2015·Epigenetics : Official Journal of the DNA Methylation Society·J M DevaneyB Kwabi-Addo

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