Explaining Resistance to CAR T Cells

Cancer Discovery

Abstract

A new study reveals several attributes of T cells from patients with chronic lymphocytic leukemia who respond to CAR T-cell therapy. The patients' T cells show increased expression of memory-related genes and high activity of STAT3, which promotes memory cell differentiation. The researchers also found that patients who underwent complete remission have certain CD8+ T cells.

Citations

May 20, 2020·Journal of Hematology & Oncology·Yonggui TianYi Zhang

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