Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study.

Human Brain Mapping
Prejaas TewarieMenno M Schoonheim

Abstract

To understand the heterogeneity of functional connectivity results reported in the literature, we analyzed the separate effects of grey and white matter damage on functional connectivity and networks in multiple sclerosis. For this, we employed a biophysical thalamo-cortical model consisting of interconnected cortical and thalamic neuronal populations, informed and amended by empirical diffusion MRI tractography data, to simulate functional data that mimic neurophysiological signals. Grey matter degeneration was simulated by decreasing within population connections and white matter degeneration by lowering between population connections, based on lesion predilection sites in multiple sclerosis. For all simulations, functional connectivity and functional network organization are quantified by phase synchronization and network integration, respectively. Modeling results showed that both cortical and thalamic grey matter damage induced a global increase in functional connectivity, whereas white matter damage induced an initially increased connectivity followed by a global decrease. Both white and especially grey matter damage, however, induced a decrease in network integration. These empirically informed simulations show that spec...Continue Reading

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Citations

Mar 4, 2020·Neurology. Neuroimmunology and Neuroinflammation·Yael BacknerNetta Levin
Jun 5, 2020·Alzheimer's Research & Therapy·Casper T BrielsAlida A Gouw
Oct 13, 2020·Brain Topography·Massimiliano ZaninJavier Cano
Oct 27, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Myrte StrikMenno M Schoonheim
Nov 27, 2020·Human Brain Mapping·Martin SjøgårdXavier De Tiège
Jan 14, 2021·Nature Reviews. Neurology·Declan T ChardUNKNOWN MAGNIMS Study Group
Sep 24, 2019·Multiple Sclerosis and Related Disorders·Mihaela Bustuchina Vlaicu
Mar 16, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Maureen van DamMenno M Schoonheim
Apr 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Menno M SchoonheimJeroen Jg Geurts
Aug 27, 2021·PloS One·Masoud SerajiBart Krekelberg
Jul 27, 2021·Brain Connectivity·Heena R ManglaniRuchika Shaurya Prakash

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