Explanation and Prediction of Clinical Data with Imbalanced Class Distribution based on Pattern Discovery and Disentanglement

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Peiyuan Zhou, Andrew K.C. Wong

Abstract

Background Statistical data analysis, especially the advanced machine learning (ML) methods, have attracted considerable interest and application in clinical practices. First, the interpretability of the diagnostic/prognostic results will bring confidence to doctors, patients and their relatives in therapeutics and clinical practice. Furthermore, from the clinical aspect, when the datasets are imbalanced in diagnostic categories, the ordinary ML methods might produce results overwhelmed by the majority classes diminishing prediction accuracy. Hence, it is desirable to have a method that could produce explicit transparent and interpretable results in decision-making, even for data with imbalanced groups.Methods In order to interpret the clinical patterns and conduct diagnostic prediction of patients, we present our new method, Pattern Discovery and Disentanglement for Clinical Data Analysis (cPDD), which is able to discover patterns (correlated traits/indicants) and use them to classify clinical data even if the class distribution is imbalanced. In the most general setting, a relational dataset is a large table such that each column represents an attribute (trait/indicant), each row contains a set of attribute values (AVs) of an...Continue Reading

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