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Explanation of the stimulation of microsomal N-demethylation reactions by soluble supernatant fraction

Research Communications in Chemical Pathology and Pharmacology

Oct 1, 1975

D L Cinti

PMID: 745

Abstract

Addition of the cell soluble supernatant fraction to an assay medium containing NADPH generating system, mixed function oxidase substrate and microsomes, resulted in a stimulation of drug metabolism ranging from 12-75%. This stimulation was observed only when the supply of DADPH generat...read more

Mentioned in this Paper

IDH3A gene
Mixed Function Oxygenases
Aminopyrine N-Demethylase
Metabolic Inhibition
Assay
Isocitrate Dehydrogenase (NAD+)
Supernatant
Lipid Peroxidation
Soluble
Microsomes
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Explanation of the stimulation of microsomal N-demethylation reactions by soluble supernatant fraction

Research Communications in Chemical Pathology and Pharmacology

Oct 1, 1975

D L Cinti

PMID: 745

DOI:

Abstract

Addition of the cell soluble supernatant fraction to an assay medium containing NADPH generating system, mixed function oxidase substrate and microsomes, resulted in a stimulation of drug metabolism ranging from 12-75%. This stimulation was observed only when the supply of DADPH generat...read more

Mentioned in this Paper

IDH3A gene
Mixed Function Oxygenases
Aminopyrine N-Demethylase
Metabolic Inhibition
Assay
Isocitrate Dehydrogenase (NAD+)
Supernatant
Lipid Peroxidation
Soluble
Microsomes

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