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Explanation of the stimulation of microsomal N-demethylation reactions by soluble supernatant fraction

Research Communications in Chemical Pathology and Pharmacology

Oct 1, 1975

D L Cinti

PMID: 745

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Abstract

Addition of the cell soluble supernatant fraction to an assay medium containing NADPH generating system, mixed function oxidase substrate and microsomes, resulted in a stimulation of drug metabolism ranging from 12-75%. This stimulation was observed only when the supply of DADPH generat...read more

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Soluble
Isocitrate Dehydrogenase (NAD+)
Supernatant
NADP
Metabolic Inhibition
Mixed Function Oxygenases
Glucosephosphate Dehydrogenase
Dealkylation
Nadph Oxidation
Lipid Peroxidation
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  • Explanation of the stimulation of microsomal N-demethylation reactions by soluble supernatant fraction

    Research Communications in Chemical Pathology and Pharmacology

    Oct 1, 1975

    D L Cinti

    PMID: 745

    DOI:

    Abstract

    Addition of the cell soluble supernatant fraction to an assay medium containing NADPH generating system, mixed function oxidase substrate and microsomes, resulted in a stimulation of drug metabolism ranging from 12-75%. This stimulation was observed only when the supply of DADPH generat...read more

    Mentioned in this Paper

    Soluble
    Isocitrate Dehydrogenase (NAD+)
    Supernatant
    NADP
    Metabolic Inhibition

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