Explanation of the variance in quality of life and activity capacity of patients with heart failure by laboratory data

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Leonidas V AthanasopoulosDennis V Cokkinos

Abstract

This study was conducted to explain the variance in quality of life (QoL) and activity capacity of patients with congestive heart failure from pathophysiological changes as estimated by laboratory data. Peak oxygen consumption (peak VO2) and ventilation (VE)/carbon dioxide output (VCO2) slope derived from cardiopulmonary exercise testing, plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and echocardiographic markers [left atrium (LA), left ventricular ejection fraction (LVEF)] were measured in 62 patients with congestive heart failure, who also completed the Minnesota Living with Heart Failure Questionnaire and the Specific Activity Questionnaire. All regression models were adjusted for age and sex. On linear regression analysis, peak VO2 with P value less than 0.001, VE/VCO2 slope with P value less than 0.01, LVEF with P value less than 0.001, LA with P=0.001, and logNT-proBNP with P value less than 0.01 were found to be associated with QoL. On stepwise multiple linear regression, peak VO2 and LVEF continued to be predictive, accounting for 40% of the variability in Minnesota Living with Heart Failure Questionnaire score. On linear regression analysis, peak VO2 with P value less than 0.001, VE/VCO2 slope...Continue Reading

References

Jun 1, 1996·The American Journal of Cardiology·S L RankinJ Hung
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Dalane W KitzmanKathryn P Stewart
Mar 4, 2003·Journal of Cardiac Failure·Barbara RiegelNancy Albert
Feb 5, 2004·American Heart Journal·Ross ArenaMary Ann Peberdy
Oct 8, 2004·Journal of Cardiac Failure·Frederick A MasoudiUNKNOWN Cardiovascular Outcomes Research Consortium
Dec 8, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ioannis LaoutarisDennis V Cokkinos
Sep 27, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Filippo Maria SarulloAntonio Castello
Dec 26, 2006·European Journal of Heart Failure·Eldrin F LewisUNKNOWN CHARM Investigators
Oct 11, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Karen MorganEmer Shelley

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Citations

Feb 5, 2013·European Journal of Internal Medicine·Martin SchererChristoph Herrmann-Lingen

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