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Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction

Genetic Epidemiology

May 23, 2015

Chia-Yen ChenAlkes L Price

Abstract

Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

Mentioned in this Paper

Genome-Wide Association Study
Tan protein, Drosophila
European American
GZMK gene
Basal Cell Carcinoma Pathway
Cross Validation
Pigmented Basal Cell Carcinoma
Oligogenic Inheritance
Pierre Robin Syndrome
Hair
2
43
Paper Details
References
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  • Citations5
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  • References51
  • Citations5
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Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction

Genetic Epidemiology

May 23, 2015

Chia-Yen ChenAlkes L Price

PMID: 25995153

DOI: 10.1002/gepi.21906

Abstract

Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

Mentioned in this Paper

Genome-Wide Association Study
Tan protein, Drosophila
European American
GZMK gene
Basal Cell Carcinoma Pathway
Cross Validation
Pigmented Basal Cell Carcinoma
Oligogenic Inheritance
Pierre Robin Syndrome
Hair
2
43

Similar Papers Found In These Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Paper Details
References
  • References51
  • Citations5
12345...
  • References51
  • Citations5
1
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