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Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction

Genetic Epidemiology

Sep 1, 2015

Chia-Yen ChenAlkes L. Price

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Abstract

Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

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  • Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction

    Genetic Epidemiology

    Sep 1, 2015

    Chia-Yen ChenAlkes L. Price

    PMID: 25995153

    DOI: 10.1002/gepi.21906

    Abstract

    Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

    2
    45

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